2W8Y

RU486 bound to the progesterone receptor in a destabilized agonistic conformation

Summary for 2W8Y

• Entry DOI: 10.2210/pdb2w8y/pdb
• Related: 1A28 1E3K 1SQN 1SR7 1ZUC 2C7A
• Descriptor: PROGESTERONE RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: receptor, progesterone receptor, ru-486, mifepristone
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• Total number of polymer chains: 2
• Total formula weight: 60822.34

Authors

Raaijmakers, H.C.A.,Versteeg, J.,Uitdehaag, J.C.M. (deposition date: 2009-01-20, release date: 2009-04-28, Last modification date: 2017-12-27)

• Primary citation: Raaijmakers, H.C.A.,Versteegh, J.,Uitdehaag, J.C.M.; The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.; J.Biol.Chem., 284:19572-, 2009; PubMed: 19372222; DOI: 10.1074/JBC.M109.007872

Experimental method

X-RAY DIFFRACTION (1.8 Å)