eF-site ID 2w8y-AB PDB Code 2w8y Chain A, B click to enlarge Title RU486 bound to the progesterone receptor in a destabilized agonistic conformation Classification RECEPTOR Compound PROGESTERONE RECEPTOR Source Homo sapiens (Human) (PRGR_HUMAN) Sequence A:  LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLG ERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFG LGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMW QIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFE EMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILA GMVKPLLFHKK B:  LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLG ERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFG LGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMW QIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFE EMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILA GMVKPLLFHKK Description (1)  PROGESTERONE RECEPTOR Functional site 1) chain A residue 715 type sequence L description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 2) chain A residue 718 type sequence L description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 3) chain A residue 719 type sequence N description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 4) chain A residue 721 type sequence L description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 5) chain A residue 722 type sequence G description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 6) chain A residue 723 type sequence E description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 7) chain A residue 725 type sequence Q description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 8) chain A residue 755 type sequence W description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 9) chain A residue 756 type sequence M description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 10) chain A residue 759 type sequence M description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 11) chain A residue 766 type sequence R description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 12) chain A residue 794 type sequence F description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 13) chain A residue 797 type sequence L description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 14) chain A residue 801 type sequence M description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 15) chain A residue 890 type sequence Y description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 16) chain A residue 891 type sequence C description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 17) chain A residue 909 type sequence M description BINDING SITE FOR RESIDUE 486 A 1000 source : AC1 18) chain B residue 715 type sequence L description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 19) chain B residue 718 type sequence L description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 20) chain B residue 719 type sequence N description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 21) chain B residue 725 type sequence Q description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 22) chain B residue 756 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 23) chain B residue 759 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 24) chain B residue 766 type sequence R description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 25) chain B residue 801 type sequence M description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 26) chain B residue 890 type sequence Y description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 27) chain B residue 891 type sequence C description BINDING SITE FOR RESIDUE NDR B 1000 source : AC2 28) chain B residue 765 type sequence W description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3 29) chain B residue 770 type sequence H description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3 30) chain B residue 815 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1934 source : AC3 31) chain A residue 737 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1934 source : AC4 32) chain A residue 738 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1934 source : AC4 33) chain A residue 740 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1934 source : AC4 34) chain A residue 741 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1934 source : AC4

Display surface Download Links