eF-site ID 2r7g-C PDB Code 2r7g Chain C click to enlarge Title Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain Classification TRANSCRIPTION REPRESSOR, CELL CYCLE Compound Retinoblastoma-associated protein Source Homo sapiens (Human) (E1A_ADE05) Sequence C:  NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRV KDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMES MLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYS RSTGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTRE MIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDRKSTSLS LFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTL QNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAY KDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNI LQYASTRPPTLSPIPHI Description Functional site 1) chain C residue 574 type sequence K description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 2) chain C residue 406 type sequence N description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 3) chain C residue 407 type sequence C description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 4) chain C residue 408 type sequence T description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 5) chain C residue 472 type sequence N description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 6) chain C residue 473 type sequence F description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 7) chain C residue 474 type sequence S description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 8) chain C residue 567 type MOD_RES sequence S description Phosphoserine; by CDK2 => ECO:0000269|PubMed:10499802 source Swiss-Prot : SWS_FT_FI1 9) chain C residue 669 type MOD_RES sequence L description Phosphoserine => ECO:0000250|UniProtKB:P13405 source Swiss-Prot : SWS_FT_FI2 10) chain C residue 673 type MOD_RES sequence H description Phosphoserine; by CHEK2 and CHEK1 => ECO:0000269|PubMed:17380128, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 685 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 12) chain C residue 780 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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