eF-site ID 2r7g-ABCDE
PDB Code 2r7g
Chain A, B, C, D, E

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Title Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
Classification TRANSCRIPTION REPRESSOR, CELL CYCLE
Compound Retinoblastoma-associated protein
Source Homo sapiens (Human) (E1A_ADE05)
Sequence A:  NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRV
KDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMES
MLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYS
RSTGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTRE
MIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDKSTSLSL
FYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQ
NEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYK
DLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNIL
QYASTRPPTLSPIPHI
B:  PPTLHELYDL
C:  NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRV
KDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMES
MLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYS
RSTGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTRE
MIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDRKSTSLS
LFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTL
QNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAY
KDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNI
LQYASTRPPTLSPIPHI
D:  PPTLHELYDL
E:  PPTLHELYD
Description


Functional site

1) chain A
residue 406
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

2) chain A
residue 407
type
sequence C
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

3) chain A
residue 408
type
sequence T
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

4) chain A
residue 472
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

5) chain A
residue 473
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

6) chain A
residue 474
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

7) chain C
residue 574
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 902
source : AC1

8) chain A
residue 574
type
sequence K
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

9) chain C
residue 406
type
sequence N
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

10) chain C
residue 407
type
sequence C
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

11) chain C
residue 408
type
sequence T
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

12) chain C
residue 472
type
sequence N
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

13) chain C
residue 473
type
sequence F
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

14) chain C
residue 474
type
sequence S
description BINDING SITE FOR RESIDUE SO4 C 901
source : AC2

15) chain A
residue 567
type MOD_RES
sequence S
description Phosphoserine; by CDK2 => ECO:0000269|PubMed:10499802
source Swiss-Prot : SWS_FT_FI1

16) chain C
residue 567
type MOD_RES
sequence S
description Phosphoserine; by CDK2 => ECO:0000269|PubMed:10499802
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 669
type MOD_RES
sequence L
description Phosphoserine => ECO:0000250|UniProtKB:P13405
source Swiss-Prot : SWS_FT_FI2

18) chain C
residue 669
type MOD_RES
sequence L
description Phosphoserine => ECO:0000250|UniProtKB:P13405
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 673
type MOD_RES
sequence H
description Phosphoserine; by CHEK2 and CHEK1 => ECO:0000269|PubMed:17380128, ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI3

20) chain C
residue 673
type MOD_RES
sequence H
description Phosphoserine; by CHEK2 and CHEK1 => ECO:0000269|PubMed:17380128, ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI3

21) chain A
residue 685
type MOD_RES
sequence Q
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

22) chain A
residue 780
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

23) chain C
residue 685
type MOD_RES
sequence Q
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

24) chain C
residue 780
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4


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