eF-site ID 2r7g-ABCDE PDB Code 2r7g Chain A, B, C, D, E click to enlarge Title Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain Classification TRANSCRIPTION REPRESSOR, CELL CYCLE Compound Retinoblastoma-associated protein Source Homo sapiens (Human) (E1A_ADE05) Sequence A:  NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRV KDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMES MLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYS RSTGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTRE MIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDKSTSLSL FYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQ NEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYK DLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNIL QYASTRPPTLSPIPHI B:  PPTLHELYDL C:  NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRV KDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMES MLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYS RSTGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTRE MIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDRKSTSLS LFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTL QNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAY KDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNI LQYASTRPPTLSPIPHI D:  PPTLHELYDL E:  PPTLHELYD Description Functional site 1) chain A residue 406 type sequence N description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 2) chain A residue 407 type sequence C description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 3) chain A residue 408 type sequence T description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 4) chain A residue 472 type sequence N description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 5) chain A residue 473 type sequence F description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 6) chain A residue 474 type sequence S description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 7) chain C residue 574 type sequence K description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 8) chain A residue 574 type sequence K description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 9) chain C residue 406 type sequence N description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 10) chain C residue 407 type sequence C description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 11) chain C residue 408 type sequence T description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 12) chain C residue 472 type sequence N description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 13) chain C residue 473 type sequence F description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 14) chain C residue 474 type sequence S description BINDING SITE FOR RESIDUE SO4 C 901 source : AC2 15) chain A residue 567 type MOD_RES sequence S description Phosphoserine; by CDK2 => ECO:0000269|PubMed:10499802 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 567 type MOD_RES sequence S description Phosphoserine; by CDK2 => ECO:0000269|PubMed:10499802 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 669 type MOD_RES sequence L description Phosphoserine => ECO:0000250|UniProtKB:P13405 source Swiss-Prot : SWS_FT_FI2 18) chain C residue 669 type MOD_RES sequence L description Phosphoserine => ECO:0000250|UniProtKB:P13405 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 673 type MOD_RES sequence H description Phosphoserine; by CHEK2 and CHEK1 => ECO:0000269|PubMed:17380128, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI3 20) chain C residue 673 type MOD_RES sequence H description Phosphoserine; by CHEK2 and CHEK1 => ECO:0000269|PubMed:17380128, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 685 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 780 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 23) chain C residue 685 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 24) chain C residue 780 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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