eF-site ID 2qrz-A
PDB Code 2qrz
Chain A

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Title Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required
Classification CELL CYCLE
Compound Cell division control protein 42 homolog precursor
Source Homo sapiens (Human) (CDC42_HUMAN)
Sequence A:  MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNY
AVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLV
CFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL
TQKGLKNVFDEAILAALEPPEPKKSRRCV
Description (1)  Cell division control protein 42 homolog precursor


Functional site

1) chain A
residue 17
type
sequence T
description BINDING SITE FOR RESIDUE MG A 190
source : AC1

2) chain A
residue 164
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 3638
source : AC3

3) chain A
residue 13
type
sequence A
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

4) chain A
residue 15
type
sequence G
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

5) chain A
residue 16
type
sequence K
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

6) chain A
residue 17
type
sequence T
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

7) chain A
residue 18
type
sequence C
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

8) chain A
residue 60
type
sequence G
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

9) chain A
residue 61
type
sequence Q
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

10) chain A
residue 116
type
sequence Q
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

11) chain A
residue 118
type
sequence D
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

12) chain A
residue 119
type
sequence L
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

13) chain A
residue 158
type
sequence S
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

14) chain A
residue 159
type
sequence A
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

15) chain A
residue 160
type
sequence L
description BINDING SITE FOR RESIDUE GCP A 3639
source : AC4

16) chain A
residue 10
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 115
type BINDING
sequence T
description
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 57
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 32
type MOD_RES
sequence Y
description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 35
type MOD_RES
sequence T
description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
source Swiss-Prot : SWS_FT_FI4

21) chain A
residue 64
type MOD_RES
sequence Y
description Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
source Swiss-Prot : SWS_FT_FI5

22) chain A
residue 188
type MOD_RES
sequence C
description Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
source Swiss-Prot : SWS_FT_FI6

23) chain A
residue 188
type LIPID
sequence C
description S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
source Swiss-Prot : SWS_FT_FI7

24) chain A
residue 32
type CARBOHYD
sequence Y
description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8

25) chain A
residue 35
type CARBOHYD
sequence T
description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
source Swiss-Prot : SWS_FT_FI9


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