eF-site ID 2qc8-H PDB Code 2qc8 Chain H click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source Homo sapiens (Human) (GLNA_HUMAN) Sequence H:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETG Description Functional site 1) chain H residue 136 type sequence E description BINDING SITE FOR RESIDUE MN H 401 source : CC4 2) chain H residue 196 type sequence E description BINDING SITE FOR RESIDUE MN H 401 source : CC4 3) chain H residue 203 type sequence E description BINDING SITE FOR RESIDUE MN H 401 source : CC4 4) chain H residue 134 type sequence E description BINDING SITE FOR RESIDUE MN H 402 source : CC5 5) chain H residue 253 type sequence H description BINDING SITE FOR RESIDUE MN H 402 source : CC5 6) chain H residue 338 type sequence E description BINDING SITE FOR RESIDUE MN H 402 source : CC5 7) chain H residue 134 type sequence E description BINDING SITE FOR RESIDUE MN H 403 source : CC6 8) chain H residue 203 type sequence E description BINDING SITE FOR RESIDUE MN H 403 source : CC6 9) chain H residue 193 type sequence T description BINDING SITE FOR RESIDUE CL G 708 source : EC2 10) chain H residue 44 type sequence T description BINDING SITE FOR RESIDUE CL I 709 source : EC3 11) chain H residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 12) chain H residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 13) chain H residue 191 type sequence A description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 14) chain H residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 15) chain H residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 16) chain H residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 17) chain H residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 18) chain H residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 19) chain H residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 20) chain H residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 21) chain H residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 22) chain H residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 23) chain H residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP H 501 source : GC1 24) chain H residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 25) chain H residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 26) chain H residue 162 type sequence Y description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 27) chain H residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 28) chain H residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 29) chain H residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 30) chain H residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 31) chain H residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 32) chain H residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 33) chain H residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 34) chain H residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 35) chain H residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 36) chain H residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S I 601 source : GC4 37) chain H residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 38) chain H residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 39) chain H residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 40) chain H residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 41) chain H residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 42) chain H residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 43) chain H residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 44) chain H residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 45) chain H residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 46) chain H residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 47) chain H residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 48) chain H residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 49) chain H residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 50) chain H residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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