Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Summary for 2QC8

DescriptorGlutamine synthetase (E.C.
Functional KeywordsAmino-acid biosynthesis, Ligase, Synthetase, Structural Genomics, Structural Genomics Consortium, SGC,LIGASE
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15104
Total number of polymer chains10
Total molecular weight442528.16
Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2007-06-19, release date: 2007-07-03, modification date: 2011-07-13)
Primary citation
Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375:217-228, 2008
PubMed: 18005987
DOI: 10.1016/j.jmb.2007.10.029
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22130.1%2.0%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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rotated about x axis by 90°
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