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2QC8

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Summary for 2QC8

Related2OJW 
DescriptorGlutamine synthetase (E.C.6.3.1.2)
Functional KeywordsAmino-acid biosynthesis, Ligase, Synthetase, Structural Genomics, Structural Genomics Consortium, SGC,LIGASE
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm 
Organ source
Total number of polymer chains10
Total molecular weight442528.16
Authors
Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2007-06-19, release date: 2007-07-03, modification date: 2011-07-13)
Primary citation
Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375:217-228, 2008
PubMed: 18005987
DOI: 10.1016/j.jmb.2007.10.029
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22130.1%2.0%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

More Asymmetric unit images

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rotated about x axis by 90°
rotated about y axis by 90°
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105025
entries available on 2014-11-19
00:00 UTC / 09:00 JST