2QC8

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

> Summary

Summary for 2QC8

Related2OJW
DescriptorGlutamine synthetase (E.C.6.3.1.2)
Functional Keywordsamino-acid biosynthesis, ligase, synthetase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15104
Total number of polymer chains10
Total molecular weight442528.16
Authors
Primary citation
Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375:217-228, 2008
PubMed: 18005987
DOI: 10.1016/j.jmb.2007.10.029
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22130.1%2.0%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2qc8
no rotation
Molmil generated image of 2qc8
rotated about x axis by 90°
Molmil generated image of 2qc8
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, B, C, D, E...Glutamine synthetasepolymer38443365.110
UniProt (P15104)
Pfam (PF00120)
Pfam (PF03951)
Homo sapiens (human)@PDBjGlutamate-ammonia ligase, GS
MANGANESE (II) IONnon-polymer54.930
CHLORIDE IONnon-polymer35.510
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.210
L-METHIONINE-S-SULFOXIMINE PHOSPHATEnon-polymer260.210
waterwater18.0231

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains10
Total molecular weight433651.5
Non-Polymers*Number of molecules60
Total molecular weight8876.7
All*Total molecular weight442528.2
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (2.6 Å)

Cell axes181.210126.080188.170
Cell angles90.0092.1490.00
SpacegroupC 1 2 1
Resolution limits39.94 - 2.60
the highest resolution shell value2.670 - 2.600
R-factor0.168
R-work0.16600
the highest resolution shell value0.239
R-free0.21700
the highest resolution shell value0.300
RMSD bond length0.015
RMSD bond angle1.592

Data Collection Statistics

Resolution limits40.00 - 2.60
the highest resolution shell value -
Number of reflections129787
Rmerge_l_obs0.120
the highest resolution shell value0.526
Completeness99.8
Redundancy7.5
the highest resolution shell value7.2
I/sigma(I)0

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
17298

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*

> Functional details

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Functional Information from GO Data

ChainGOidnamespacecontents
A0043679cellular_componentaxon terminus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0070062cellular_componentextracellular exosome
A0097386cellular_componentglial cell projection
A0005739cellular_componentmitochondrion
A0043209cellular_componentmyelin sheath
A0005634cellular_componentnucleus
A0043204cellular_componentperikaryon
A0043234cellular_componentprotein complex
A0005791cellular_componentrough endoplasmic reticulum
A0005524molecular_functionATP binding
A0016595molecular_functionglutamate binding
A0004351molecular_functionglutamate decarboxylase activity
A0004356molecular_functionglutamate-ammonia ligase activity
A0042802molecular_functionidentical protein binding
A0000287molecular_functionmagnesium ion binding
A0030145molecular_functionmanganese ion binding
A0019676biological_processammonia assimilation cycle
A0008283biological_processcell proliferation
A0008652biological_processcellular amino acid biosynthetic process
A0009267biological_processcellular response to starvation
A0006538biological_processglutamate catabolic process
A0006542biological_processglutamine biosynthetic process
A0001504biological_processneurotransmitter uptake
A0050679biological_processpositive regulation of epithelial cell proliferation
A0032024biological_processpositive regulation of insulin secretion
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0051260biological_processprotein homooligomerization
A0009749biological_processresponse to glucose
B0043679cellular_componentaxon terminus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0070062cellular_componentextracellular exosome
B0097386cellular_componentglial cell projection
B0005739cellular_componentmitochondrion
B0043209cellular_componentmyelin sheath
B0005634cellular_componentnucleus
B0043204cellular_componentperikaryon
B0043234cellular_componentprotein complex
B0005791cellular_componentrough endoplasmic reticulum
B0005524molecular_functionATP binding
B0016595molecular_functionglutamate binding
B0004351molecular_functionglutamate decarboxylase activity
B0004356molecular_functionglutamate-ammonia ligase activity
B0042802molecular_functionidentical protein binding
B0000287molecular_functionmagnesium ion binding
B0030145molecular_functionmanganese ion binding
B0019676biological_processammonia assimilation cycle
B0008283biological_processcell proliferation
B0008652biological_processcellular amino acid biosynthetic process
B0009267biological_processcellular response to starvation
B0006538biological_processglutamate catabolic process
B0006542biological_processglutamine biosynthetic process
B0001504biological_processneurotransmitter uptake
B0050679biological_processpositive regulation of epithelial cell proliferation
B0032024biological_processpositive regulation of insulin secretion
B0051968biological_processpositive regulation of synaptic transmission, glutamatergic
B0051260biological_processprotein homooligomerization
B0009749biological_processresponse to glucose
C0043679cellular_componentaxon terminus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0070062cellular_componentextracellular exosome
C0097386cellular_componentglial cell projection
C0005739cellular_componentmitochondrion
C0043209cellular_componentmyelin sheath
C0005634cellular_componentnucleus
C0043204cellular_componentperikaryon
C0043234cellular_componentprotein complex
C0005791cellular_componentrough endoplasmic reticulum
C0005524molecular_functionATP binding
C0016595molecular_functionglutamate binding
C0004351molecular_functionglutamate decarboxylase activity
C0004356molecular_functionglutamate-ammonia ligase activity
C0042802molecular_functionidentical protein binding
C0000287molecular_functionmagnesium ion binding
C0030145molecular_functionmanganese ion binding
C0019676biological_processammonia assimilation cycle
C0008283biological_processcell proliferation
C0008652biological_processcellular amino acid biosynthetic process
C0009267biological_processcellular response to starvation
C0006538biological_processglutamate catabolic process
C0006542biological_processglutamine biosynthetic process
C0001504biological_processneurotransmitter uptake
C0050679biological_processpositive regulation of epithelial cell proliferation
C0032024biological_processpositive regulation of insulin secretion
C0051968biological_processpositive regulation of synaptic transmission, glutamatergic
C0051260biological_processprotein homooligomerization
C0009749biological_processresponse to glucose
D0043679cellular_componentaxon terminus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0070062cellular_componentextracellular exosome
D0097386cellular_componentglial cell projection
D0005739cellular_componentmitochondrion
D0043209cellular_componentmyelin sheath
D0005634cellular_componentnucleus
D0043204cellular_componentperikaryon
D0043234cellular_componentprotein complex
D0005791cellular_componentrough endoplasmic reticulum
D0005524molecular_functionATP binding
D0016595molecular_functionglutamate binding
D0004351molecular_functionglutamate decarboxylase activity
D0004356molecular_functionglutamate-ammonia ligase activity
D0042802molecular_functionidentical protein binding
D0000287molecular_functionmagnesium ion binding
D0030145molecular_functionmanganese ion binding
D0019676biological_processammonia assimilation cycle
D0008283biological_processcell proliferation
D0008652biological_processcellular amino acid biosynthetic process
D0009267biological_processcellular response to starvation
D0006538biological_processglutamate catabolic process
D0006542biological_processglutamine biosynthetic process
D0001504biological_processneurotransmitter uptake
D0050679biological_processpositive regulation of epithelial cell proliferation
D0032024biological_processpositive regulation of insulin secretion
D0051968biological_processpositive regulation of synaptic transmission, glutamatergic
D0051260biological_processprotein homooligomerization
D0009749biological_processresponse to glucose
E0043679cellular_componentaxon terminus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0070062cellular_componentextracellular exosome
E0097386cellular_componentglial cell projection
E0005739cellular_componentmitochondrion
E0043209cellular_componentmyelin sheath
E0005634cellular_componentnucleus
E0043204cellular_componentperikaryon
E0043234cellular_componentprotein complex
E0005791cellular_componentrough endoplasmic reticulum
E0005524molecular_functionATP binding
E0016595molecular_functionglutamate binding
E0004351molecular_functionglutamate decarboxylase activity
E0004356molecular_functionglutamate-ammonia ligase activity
E0042802molecular_functionidentical protein binding
E0000287molecular_functionmagnesium ion binding
E0030145molecular_functionmanganese ion binding
E0019676biological_processammonia assimilation cycle
E0008283biological_processcell proliferation
E0008652biological_processcellular amino acid biosynthetic process
E0009267biological_processcellular response to starvation
E0006538biological_processglutamate catabolic process
E0006542biological_processglutamine biosynthetic process
E0001504biological_processneurotransmitter uptake
E0050679biological_processpositive regulation of epithelial cell proliferation
E0032024biological_processpositive regulation of insulin secretion
E0051968biological_processpositive regulation of synaptic transmission, glutamatergic
E0051260biological_processprotein homooligomerization
E0009749biological_processresponse to glucose
F0043679cellular_componentaxon terminus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0070062cellular_componentextracellular exosome
F0097386cellular_componentglial cell projection
F0005739cellular_componentmitochondrion
F0043209cellular_componentmyelin sheath
F0005634cellular_componentnucleus
F0043204cellular_componentperikaryon
F0043234cellular_componentprotein complex
F0005791cellular_componentrough endoplasmic reticulum
F0005524molecular_functionATP binding
F0016595molecular_functionglutamate binding
F0004351molecular_functionglutamate decarboxylase activity
F0004356molecular_functionglutamate-ammonia ligase activity
F0042802molecular_functionidentical protein binding
F0000287molecular_functionmagnesium ion binding
F0030145molecular_functionmanganese ion binding
F0019676biological_processammonia assimilation cycle
F0008283biological_processcell proliferation
F0008652biological_processcellular amino acid biosynthetic process
F0009267biological_processcellular response to starvation
F0006538biological_processglutamate catabolic process
F0006542biological_processglutamine biosynthetic process
F0001504biological_processneurotransmitter uptake
F0050679biological_processpositive regulation of epithelial cell proliferation
F0032024biological_processpositive regulation of insulin secretion
F0051968biological_processpositive regulation of synaptic transmission, glutamatergic
F0051260biological_processprotein homooligomerization
F0009749biological_processresponse to glucose
G0043679cellular_componentaxon terminus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0070062cellular_componentextracellular exosome
G0097386cellular_componentglial cell projection
G0005739cellular_componentmitochondrion
G0043209cellular_componentmyelin sheath
G0005634cellular_componentnucleus
G0043204cellular_componentperikaryon
G0043234cellular_componentprotein complex
G0005791cellular_componentrough endoplasmic reticulum
G0005524molecular_functionATP binding
G0016595molecular_functionglutamate binding
G0004351molecular_functionglutamate decarboxylase activity
G0004356molecular_functionglutamate-ammonia ligase activity
G0042802molecular_functionidentical protein binding
G0000287molecular_functionmagnesium ion binding
G0030145molecular_functionmanganese ion binding
G0019676biological_processammonia assimilation cycle
G0008283biological_processcell proliferation
G0008652biological_processcellular amino acid biosynthetic process
G0009267biological_processcellular response to starvation
G0006538biological_processglutamate catabolic process
G0006542biological_processglutamine biosynthetic process
G0001504biological_processneurotransmitter uptake
G0050679biological_processpositive regulation of epithelial cell proliferation
G0032024biological_processpositive regulation of insulin secretion
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0051260biological_processprotein homooligomerization
G0009749biological_processresponse to glucose
H0043679cellular_componentaxon terminus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0070062cellular_componentextracellular exosome
H0097386cellular_componentglial cell projection
H0005739cellular_componentmitochondrion
H0043209cellular_componentmyelin sheath
H0005634cellular_componentnucleus
H0043204cellular_componentperikaryon
H0043234cellular_componentprotein complex
H0005791cellular_componentrough endoplasmic reticulum
H0005524molecular_functionATP binding
H0016595molecular_functionglutamate binding
H0004351molecular_functionglutamate decarboxylase activity
H0004356molecular_functionglutamate-ammonia ligase activity
H0042802molecular_functionidentical protein binding
H0000287molecular_functionmagnesium ion binding
H0030145molecular_functionmanganese ion binding
H0019676biological_processammonia assimilation cycle
H0008283biological_processcell proliferation
H0008652biological_processcellular amino acid biosynthetic process
H0009267biological_processcellular response to starvation
H0006538biological_processglutamate catabolic process
H0006542biological_processglutamine biosynthetic process
H0001504biological_processneurotransmitter uptake
H0050679biological_processpositive regulation of epithelial cell proliferation
H0032024biological_processpositive regulation of insulin secretion
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0051260biological_processprotein homooligomerization
H0009749biological_processresponse to glucose
I0043679cellular_componentaxon terminus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0070062cellular_componentextracellular exosome
I0097386cellular_componentglial cell projection
I0005739cellular_componentmitochondrion
I0043209cellular_componentmyelin sheath
I0005634cellular_componentnucleus
I0043204cellular_componentperikaryon
I0043234cellular_componentprotein complex
I0005791cellular_componentrough endoplasmic reticulum
I0005524molecular_functionATP binding
I0016595molecular_functionglutamate binding
I0004351molecular_functionglutamate decarboxylase activity
I0004356molecular_functionglutamate-ammonia ligase activity
I0042802molecular_functionidentical protein binding
I0000287molecular_functionmagnesium ion binding
I0030145molecular_functionmanganese ion binding
I0019676biological_processammonia assimilation cycle
I0008283biological_processcell proliferation
I0008652biological_processcellular amino acid biosynthetic process
I0009267biological_processcellular response to starvation
I0006538biological_processglutamate catabolic process
I0006542biological_processglutamine biosynthetic process
I0001504biological_processneurotransmitter uptake
I0050679biological_processpositive regulation of epithelial cell proliferation
I0032024biological_processpositive regulation of insulin secretion
I0051968biological_processpositive regulation of synaptic transmission, glutamatergic
I0051260biological_processprotein homooligomerization
I0009749biological_processresponse to glucose
J0043679cellular_componentaxon terminus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0070062cellular_componentextracellular exosome
J0097386cellular_componentglial cell projection
J0005739cellular_componentmitochondrion
J0043209cellular_componentmyelin sheath
J0005634cellular_componentnucleus
J0043204cellular_componentperikaryon
J0043234cellular_componentprotein complex
J0005791cellular_componentrough endoplasmic reticulum
J0005524molecular_functionATP binding
J0016595molecular_functionglutamate binding
J0004351molecular_functionglutamate decarboxylase activity
J0004356molecular_functionglutamate-ammonia ligase activity
J0042802molecular_functionidentical protein binding
J0000287molecular_functionmagnesium ion binding
J0030145molecular_functionmanganese ion binding
J0019676biological_processammonia assimilation cycle
J0008283biological_processcell proliferation
J0008652biological_processcellular amino acid biosynthetic process
J0009267biological_processcellular response to starvation
J0006538biological_processglutamate catabolic process
J0006542biological_processglutamine biosynthetic process
J0001504biological_processneurotransmitter uptake
J0050679biological_processpositive regulation of epithelial cell proliferation
J0032024biological_processpositive regulation of insulin secretion
J0051968biological_processpositive regulation of synaptic transmission, glutamatergic
J0051260biological_processprotein homooligomerization
J0009749biological_processresponse to glucose
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE MN A 401
ChainResidue
AGLU155
AGLU215
AGLU222
AMN
AP3S
AHOH

AC26BINDING SITE FOR RESIDUE MN A 402
ChainResidue
AGLU153
AHIS272
AGLU357
AARG359
AADP
AP3S

AC36BINDING SITE FOR RESIDUE MN A 403
ChainResidue
AGLU153
AGLU222
AMN
AADP
AP3S
AHOH

AC46BINDING SITE FOR RESIDUE MN B 401
ChainResidue
BGLU155
BGLU215
BGLU222
BMN
BP3S
BHOH

AC57BINDING SITE FOR RESIDUE MN B 402
ChainResidue
BGLU153
BHIS272
BGLU357
BARG359
BMN
BADP
BP3S

AC67BINDING SITE FOR RESIDUE MN B 403
ChainResidue
BGLU153
BGLU222
BMN
BMN
BADP
BP3S
BHOH

AC76BINDING SITE FOR RESIDUE MN C 401
ChainResidue
CGLU155
CGLU215
CGLU222
CMN
CP3S
CHOH

AC86BINDING SITE FOR RESIDUE MN C 402
ChainResidue
CGLU153
CHIS272
CGLU357
CARG359
CADP
CP3S

AC96BINDING SITE FOR RESIDUE MN C 403
ChainResidue
CGLU153
CGLU222
CMN
CADP
CP3S
CHOH

BC15BINDING SITE FOR RESIDUE MN D 401
ChainResidue
DGLU155
DGLU215
DGLU222
DMN
DP3S

BC25BINDING SITE FOR RESIDUE MN D 402
ChainResidue
DGLU153
DHIS272
DGLU357
DADP
DP3S

BC36BINDING SITE FOR RESIDUE MN D 403
ChainResidue
DGLU153
DGLU222
DMN
DADP
DP3S
DHOH

BC45BINDING SITE FOR RESIDUE MN E 401
ChainResidue
EGLU155
EGLU215
EGLU222
EP3S
EHOH

BC56BINDING SITE FOR RESIDUE MN E 402
ChainResidue
EGLU153
EHIS272
EGLU357
EARG359
EADP
EP3S

BC65BINDING SITE FOR RESIDUE MN E 403
ChainResidue
EGLU153
EGLU222
EADP
EP3S
EHOH

BC75BINDING SITE FOR RESIDUE MN F 401
ChainResidue
FGLU155
FGLU215
FGLU222
FMN
FP3S

BC86BINDING SITE FOR RESIDUE MN F 402
ChainResidue
FGLU153
FHIS272
FGLU357
FARG359
FADP
FP3S

BC96BINDING SITE FOR RESIDUE MN F 403
ChainResidue
FGLU153
FGLU222
FMN
FADP
FP3S
FHOH

CC15BINDING SITE FOR RESIDUE MN G 401
ChainResidue
GGLU155
GGLU215
GGLU222
GMN
GP3S

CC25BINDING SITE FOR RESIDUE MN G 402
ChainResidue
GGLU153
GHIS272
GGLU357
GADP
GP3S

CC35BINDING SITE FOR RESIDUE MN G 403
ChainResidue
GGLU153
GGLU222
GMN
GADP
GP3S

CC46BINDING SITE FOR RESIDUE MN H 401
ChainResidue
HGLU155
HGLU215
HGLU222
HMN
HP3S
HHOH

CC56BINDING SITE FOR RESIDUE MN H 402
ChainResidue
HGLU153
HHIS272
HGLU357
HMN
HADP
HP3S

CC67BINDING SITE FOR RESIDUE MN H 403
ChainResidue
HGLU153
HGLU222
HMN
HMN
HADP
HP3S
HHOH

CC75BINDING SITE FOR RESIDUE MN I 401
ChainResidue
IGLU155
IGLU215
IGLU222
IMN
IP3S

CC86BINDING SITE FOR RESIDUE MN I 402
ChainResidue
IGLU153
IHIS272
IGLU357
IARG359
IADP
IP3S

CC96BINDING SITE FOR RESIDUE MN I 403
ChainResidue
IGLU153
IGLU222
IMN
IADP
IP3S
IHOH

DC16BINDING SITE FOR RESIDUE MN J 401
ChainResidue
JGLU155
JGLU215
JGLU222
JMN
JP3S
JHOH

DC25BINDING SITE FOR RESIDUE MN J 402
ChainResidue
JGLU153
JHIS272
JGLU357
JADP
JP3S

DC36BINDING SITE FOR RESIDUE MN J 403
ChainResidue
JGLU153
JGLU222
JMN
JADP
JP3S
JHOH

DC43BINDING SITE FOR RESIDUE CL B 701
ChainResidue
BMET48
BTHR63
CTHR212

DC54BINDING SITE FOR RESIDUE CL C 702
ChainResidue
CMET48
CTHR63
DTHR212
DHOH

DC63BINDING SITE FOR RESIDUE CL A 703
ChainResidue
ATHR212
EMET48
ETHR63

DC72BINDING SITE FOR RESIDUE CL D 704
ChainResidue
DTHR63
ETHR212

DC83BINDING SITE FOR RESIDUE CL B 705
ChainResidue
AMET48
ATHR63
BTHR212

DC92BINDING SITE FOR RESIDUE CL F 706
ChainResidue
FTHR212
JTHR63

EC12BINDING SITE FOR RESIDUE CL G 707
ChainResidue
FTHR63
GTHR212

EC24BINDING SITE FOR RESIDUE CL G 708
ChainResidue
GMET48
GLYS62
GTHR63
HTHR212

EC32BINDING SITE FOR RESIDUE CL I 709
ChainResidue
HTHR63
ITHR212

EC42BINDING SITE FOR RESIDUE CL J 710
ChainResidue
ITHR63
JTHR212

EC520BINDING SITE FOR RESIDUE ADP A 501
ChainResidue
ATRP149
AGLY151
AGLU153
AGLU222
AGLN224
AGLY226
APRO227
AASN274
ASER276
AARG281
AARG338
AARG343
ATYR355
AGLU357
AMN
AMN
AP3S
AHOH
AHOH
AHOH

EC620BINDING SITE FOR RESIDUE P3S A 601
ChainResidue
AGLU153
AGLU155
AGLU215
AGLU222
AGLY268
AHIS272
AARG318
AGLU324
ATHR325
AARG338
AGLU357
AARG359
AMN
AMN
AMN
AADP
AHOH
AHOH
AHOH
EASP82

EC719BINDING SITE FOR RESIDUE ADP B 501
ChainResidue
AHOH
BTRP149
BGLY151
BGLU153
BGLU222
BGLN224
BILE225
BGLY226
BPRO227
BASN274
BSER276
BARG338
BARG343
BTYR355
BGLU357
BMN
BMN
BP3S
BHOH

EC820BINDING SITE FOR RESIDUE P3S B 601
ChainResidue
AASP82
BGLU153
BGLU155
BTYR181
BGLU215
BGLU222
BGLY268
BHIS272
BARG318
BGLU324
BTHR325
BARG338
BGLU357
BARG359
BMN
BMN
BMN
BADP
BHOH
BHOH

EC919BINDING SITE FOR RESIDUE ADP C 501
ChainResidue
CTRP149
CGLY151
CGLU153
CGLU222
CGLN224
CGLY226
CPRO227
CASN274
CSER276
CARG343
CTYR355
CGLU357
CMN
CMN
CP3S
CHOH
CHOH
CHOH
CHOH

FC121BINDING SITE FOR RESIDUE P3S C 601
ChainResidue
BASP82
CGLU153
CGLU155
CTYR181
CGLU215
CGLU222
CGLY268
CHIS272
CARG318
CGLU324
CTHR325
CARG338
CGLU357
CARG359
CMN
CMN
CMN
CADP
CHOH
CHOH
CHOH

FC218BINDING SITE FOR RESIDUE ADP D 501
ChainResidue
CHOH
DTRP149
DGLY151
DGLU153
DGLU222
DGLN224
DGLY226
DPRO227
DASN274
DSER276
DARG338
DARG343
DTYR355
DGLU357
DMN
DMN
DP3S
DHOH

FC318BINDING SITE FOR RESIDUE P3S D 601
ChainResidue
CASP82
DGLU153
DGLU155
DGLU215
DGLU222
DGLY268
DHIS272
DARG318
DGLU324
DTHR325
DARG338
DGLU357
DARG359
DMN
DMN
DMN
DADP
DHOH

FC420BINDING SITE FOR RESIDUE ADP E 501
ChainResidue
DHOH
ETRP149
EGLY151
EGLU153
EGLU222
EGLN224
EGLY226
EPRO227
EASN274
ESER276
EARG338
EARG343
ETYR355
EGLU357
EMN
EMN
EP3S
EHOH
EHOH
EHOH

FC518BINDING SITE FOR RESIDUE P3S E 601
ChainResidue
DASP82
EGLU153
EGLU155
EGLU215
EGLU222
EGLY268
EHIS272
EARG318
EGLU324
ETHR325
EARG338
EGLU357
EARG359
EMN
EMN
EMN
EADP
EHOH

FC620BINDING SITE FOR RESIDUE ADP F 501
ChainResidue
FTRP149
FGLY151
FGLU153
FALA210
FGLU222
FGLN224
FILE225
FGLY226
FPRO227
FASN274
FSER276
FARG338
FARG343
FTYR355
FGLU357
FMN
FMN
FP3S
FHOH
FHOH

FC718BINDING SITE FOR RESIDUE P3S F 601
ChainResidue
FGLU153
FGLU155
FGLU215
FGLU222
FGLY268
FHIS272
FARG318
FGLU324
FTHR325
FARG338
FARG359
FMN
FMN
FMN
FADP
FHOH
FHOH
JASP82

FC818BINDING SITE FOR RESIDUE ADP G 501
ChainResidue
GTRP149
GGLY151
GGLU153
GALA210
GGLU222
GGLN224
GILE225
GGLY226
GPRO227
GASN274
GSER276
GARG338
GARG343
GTYR355
GGLU357
GMN
GMN
GP3S

FC918BINDING SITE FOR RESIDUE P3S G 601
ChainResidue
FASP82
GGLU153
GGLU155
GGLU215
GGLU222
GASN267
GGLY268
GHIS272
GARG318
GGLU324
GTHR325
GARG338
GGLU357
GARG359
GMN
GMN
GMN
GADP

GC117BINDING SITE FOR RESIDUE ADP H 501
ChainResidue
HGLY151
HGLU153
HALA210
HGLU222
HGLN224
HGLY226
HPRO227
HASN274
HSER276
HARG338
HARG343
HTYR355
HGLU357
HMN
HMN
HP3S
HHOH

GC218BINDING SITE FOR RESIDUE P3S H 601
ChainResidue
GASP82
HGLU153
HGLU155
HTYR181
HGLU215
HGLU222
HGLY268
HHIS272
HARG318
HGLU324
HARG338
HGLU357
HARG359
HMN
HMN
HMN
HADP
HHOH

GC319BINDING SITE FOR RESIDUE ADP I 501
ChainResidue
ITRP149
IGLY151
IGLU153
IGLU222
IGLN224
IILE225
IGLY226
IPRO227
IASN274
ISER276
IARG338
IARG343
ITYR355
IGLU357
IMN
IMN
IP3S
IHOH
IHOH

GC419BINDING SITE FOR RESIDUE P3S I 601
ChainResidue
HASP82
IGLU153
IGLU155
IGLU215
IGLU222
IASN267
IGLY268
IGLY270
IHIS272
IARG318
IGLU324
IARG338
IARG343
IGLU357
IARG359
IMN
IMN
IMN
IADP

GC518BINDING SITE FOR RESIDUE ADP J 501
ChainResidue
JTRP149
JGLY151
JGLU153
JALA210
JGLU222
JGLN224
JGLY226
JPRO227
JASN274
JSER276
JARG338
JARG343
JTYR355
JGLU357
JMN
JMN
JP3S
JHOH

GC620BINDING SITE FOR RESIDUE P3S J 601
ChainResidue
IASP82
JGLU153
JGLU155
JTYR181
JGLU215
JGLU222
JGLY268
JHIS272
JARG318
JGLU324
JTHR325
JARG338
JGLU357
JARG359
JMN
JMN
JMN
JADP
JHOH
JHOH

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ADP_2qc8_B_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
ALYS43ADP: ADENOSINE-5'-DIPHOSPHATE
ATRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
BTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
BALA191ADP: ADENOSINE-5'-DIPHOSPHATE
BASN194ADP: ADENOSINE-5'-DIPHOSPHATE
BGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
BGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
BHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
BASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
BARG262ADP: ADENOSINE-5'-DIPHOSPHATE
BARG319ADP: ADENOSINE-5'-DIPHOSPHATE
BARG324ADP: ADENOSINE-5'-DIPHOSPHATE
BGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
BGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
BARG340ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_B_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
AASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ASER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_A_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
ATRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
AALA191ADP: ADENOSINE-5'-DIPHOSPHATE
AASN194ADP: ADENOSINE-5'-DIPHOSPHATE
AGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
AGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
AHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
AASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
AARG262ADP: ADENOSINE-5'-DIPHOSPHATE
AARG319ADP: ADENOSINE-5'-DIPHOSPHATE
AARG324ADP: ADENOSINE-5'-DIPHOSPHATE
AGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
AGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
AARG340ADP: ADENOSINE-5'-DIPHOSPHATE
ELYS43ADP: ADENOSINE-5'-DIPHOSPHATE
ETRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_A_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
AGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ATYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
AARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ESER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_C_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
BLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
BTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
CTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
CALA191ADP: ADENOSINE-5'-DIPHOSPHATE
CASN194ADP: ADENOSINE-5'-DIPHOSPHATE
CGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
CGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
CHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
CASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
CARG262ADP: ADENOSINE-5'-DIPHOSPHATE
CARG319ADP: ADENOSINE-5'-DIPHOSPHATE
CARG324ADP: ADENOSINE-5'-DIPHOSPHATE
CGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
CGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
CARG340ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_C_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
BASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
BSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_D_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
CLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
CTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
DTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
DALA191ADP: ADENOSINE-5'-DIPHOSPHATE
DASN194ADP: ADENOSINE-5'-DIPHOSPHATE
DGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
DGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
DHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
DASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
DARG262ADP: ADENOSINE-5'-DIPHOSPHATE
DARG319ADP: ADENOSINE-5'-DIPHOSPHATE
DARG324ADP: ADENOSINE-5'-DIPHOSPHATE
DGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
DGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
DARG340ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_D_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
CASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
CSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_E_50125ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
DLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
DTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
ETRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
EALA191ADP: ADENOSINE-5'-DIPHOSPHATE
EASN194ADP: ADENOSINE-5'-DIPHOSPHATE
EGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
EGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
EHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
EASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
EARG262ADP: ADENOSINE-5'-DIPHOSPHATE
EARG319ADP: ADENOSINE-5'-DIPHOSPHATE
EARG324ADP: ADENOSINE-5'-DIPHOSPHATE
EGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
EGLU338ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_E_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
DASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
DSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ETYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
EARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_G_50124ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
FLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
FTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
GTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
GALA191ADP: ADENOSINE-5'-DIPHOSPHATE
GGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
GGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
GHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
GASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
GARG262ADP: ADENOSINE-5'-DIPHOSPHATE
GARG319ADP: ADENOSINE-5'-DIPHOSPHATE
GARG324ADP: ADENOSINE-5'-DIPHOSPHATE
GGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
GGLU338ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_G_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
FASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_F_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
FTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
FALA191ADP: ADENOSINE-5'-DIPHOSPHATE
FASN194ADP: ADENOSINE-5'-DIPHOSPHATE
FGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
FGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
FHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
FASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
FARG262ADP: ADENOSINE-5'-DIPHOSPHATE
FARG319ADP: ADENOSINE-5'-DIPHOSPHATE
FARG324ADP: ADENOSINE-5'-DIPHOSPHATE
FGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
FGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
FARG340ADP: ADENOSINE-5'-DIPHOSPHATE
JLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
JTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_F_60122L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
FGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
FARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_H_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
GLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
GTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
HTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
HALA191ADP: ADENOSINE-5'-DIPHOSPHATE
HASN194ADP: ADENOSINE-5'-DIPHOSPHATE
HGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
HGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
HHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
HASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
HARG262ADP: ADENOSINE-5'-DIPHOSPHATE
HARG319ADP: ADENOSINE-5'-DIPHOSPHATE
HARG324ADP: ADENOSINE-5'-DIPHOSPHATE
HGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
HGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
HARG340ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_H_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
GASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
GSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_I_50126ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
HLYS43ADP: ADENOSINE-5'-DIPHOSPHATE
HTRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
ITRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
IALA191ADP: ADENOSINE-5'-DIPHOSPHATE
IASN194ADP: ADENOSINE-5'-DIPHOSPHATE
IGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
IGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
IHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
IASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
IARG262ADP: ADENOSINE-5'-DIPHOSPHATE
IARG319ADP: ADENOSINE-5'-DIPHOSPHATE
IARG324ADP: ADENOSINE-5'-DIPHOSPHATE
IGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
IGLU338ADP: ADENOSINE-5'-DIPHOSPHATE
IARG340ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_I_60122L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
HASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
HSER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ITYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
IARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

ADP_2qc8_J_50125ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
ILYS43ADP: ADENOSINE-5'-DIPHOSPHATE
ITRP60-ASN61ADP: ADENOSINE-5'-DIPHOSPHATE
JTRP130-GLU134ADP: ADENOSINE-5'-DIPHOSPHATE
JALA191ADP: ADENOSINE-5'-DIPHOSPHATE
JASN194ADP: ADENOSINE-5'-DIPHOSPHATE
JGLU203ADP: ADENOSINE-5'-DIPHOSPHATE
JGLN205-PRO208ADP: ADENOSINE-5'-DIPHOSPHATE
JHIS253ADP: ADENOSINE-5'-DIPHOSPHATE
JASN255-SER257ADP: ADENOSINE-5'-DIPHOSPHATE
JARG262ADP: ADENOSINE-5'-DIPHOSPHATE
JARG319ADP: ADENOSINE-5'-DIPHOSPHATE
JARG324ADP: ADENOSINE-5'-DIPHOSPHATE
JGLY335-TYR336ADP: ADENOSINE-5'-DIPHOSPHATE
JGLU338ADP: ADENOSINE-5'-DIPHOSPHATE

P3S_2qc8_J_60123L-METHIONINE-S-SULFOXIMINE PHOSPHATE binding site
ChainResidueligand
IASP63P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
ISER66P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLU134P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLU136P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JTYR162P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JASN194P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLU196-VAL197P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLN201P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLU203P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JASN248-GLY251P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JHIS253P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JARG299P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JHIS304-THR306P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JARG319P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JARG324P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JGLU338P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE
JARG340P3S: L-METHIONINE-S-SULFOXIMINE PHOSPHATE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0018010Glutamine synthetase signature 1. [FYWL]-D-G-S-S-x(6,8)-[DENQSTAK]-[SA]-[DE]-x(2)-[LIVMFY]
ChainResidueDetails
ANA*
BNA*
CNA*
DNA*
ENA*
FNA*
GNA*
HNA*
INA*
JNA*

PS0018110Glutamine synthetase putative ATP-binding region signature. K-P-[LIVMFYA]-x(3,5)-[NPAT]-[GA]-[GSTAN]-[GA]-x-H-x(3)-S
ChainResidueDetails
ANA*
BNA*
CNA*
DNA*
ENA*
FNA*
GNA*
HNA*
INA*
JNA*

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA13Annotated By Reference To The Literature 1hto
ChainResidueDetails
AARG319
AGLU305
AASP63

CSA23Annotated By Reference To The Literature 1hto
ChainResidueDetails
BARG319
BGLU305
BASP63

CSA33Annotated By Reference To The Literature 1hto
ChainResidueDetails
CARG319
CGLU305
CASP63

CSA43Annotated By Reference To The Literature 1hto
ChainResidueDetails
DARG319
DGLU305
DASP63

CSA53Annotated By Reference To The Literature 1hto
ChainResidueDetails
EARG319
EGLU305
EASP63

CSA63Annotated By Reference To The Literature 1hto
ChainResidueDetails
FARG319
FGLU305
FASP63

CSA73Annotated By Reference To The Literature 1hto
ChainResidueDetails
GARG319
GGLU305
GASP63

CSA83Annotated By Reference To The Literature 1hto
ChainResidueDetails
HARG319
HGLU305
HASP63

CSA93Annotated By Reference To The Literature 1hto
ChainResidueDetails
IARG319
IGLU305
IASP63

CSA103Annotated By Reference To The Literature 1hto
ChainResidueDetails
JARG319
JGLU305
JASP63

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Catalytic Information from CATRES

site_idNumber of ResiduesDetails

> Sequence Neighbor

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