Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Summary for 2QC8

DescriptorGlutamine synthetase (E.C.
Functional Keywordsamino-acid biosynthesis, ligase, synthetase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15104
Total number of polymer chains10
Total molecular weight442528.16
Primary citation
Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L.
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375:217-228, 2008
PubMed: 18005987
DOI: 10.1016/j.jmb.2007.10.029
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22130.1%2.0%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2qc8
no rotation
Molmil generated image of 2qc8
rotated about x axis by 90°
Molmil generated image of 2qc8
rotated about y axis by 90°
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