eF-site ID 2qc8-G PDB Code 2qc8 Chain G click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source Homo sapiens (Human) (GLNA_HUMAN) Sequence G:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETG Description Functional site 1) chain G residue 136 type sequence E description BINDING SITE FOR RESIDUE MN G 401 source : CC1 2) chain G residue 196 type sequence E description BINDING SITE FOR RESIDUE MN G 401 source : CC1 3) chain G residue 203 type sequence E description BINDING SITE FOR RESIDUE MN G 401 source : CC1 4) chain G residue 134 type sequence E description BINDING SITE FOR RESIDUE MN G 402 source : CC2 5) chain G residue 253 type sequence H description BINDING SITE FOR RESIDUE MN G 402 source : CC2 6) chain G residue 338 type sequence E description BINDING SITE FOR RESIDUE MN G 402 source : CC2 7) chain G residue 134 type sequence E description BINDING SITE FOR RESIDUE MN G 403 source : CC3 8) chain G residue 203 type sequence E description BINDING SITE FOR RESIDUE MN G 403 source : CC3 9) chain G residue 193 type sequence T description BINDING SITE FOR RESIDUE CL G 707 source : EC1 10) chain G residue 29 type sequence M description BINDING SITE FOR RESIDUE CL G 708 source : EC2 11) chain G residue 43 type sequence K description BINDING SITE FOR RESIDUE CL G 708 source : EC2 12) chain G residue 44 type sequence T description BINDING SITE FOR RESIDUE CL G 708 source : EC2 13) chain G residue 130 type sequence W description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 14) chain G residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 15) chain G residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 16) chain G residue 191 type sequence A description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 17) chain G residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 18) chain G residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 19) chain G residue 206 type sequence I description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 20) chain G residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 21) chain G residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 22) chain G residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 23) chain G residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 24) chain G residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 25) chain G residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 26) chain G residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 27) chain G residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP G 501 source : FC8 28) chain G residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 29) chain G residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 30) chain G residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 31) chain G residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 32) chain G residue 248 type sequence N description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 33) chain G residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 34) chain G residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 35) chain G residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 36) chain G residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 37) chain G residue 306 type sequence T description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 38) chain G residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 39) chain G residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 40) chain G residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S G 601 source : FC9 41) chain G residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S H 601 source : GC2 42) chain G residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 43) chain G residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 44) chain G residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 45) chain G residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 46) chain G residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 47) chain G residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 48) chain G residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 49) chain G residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 50) chain G residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 51) chain G residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 52) chain G residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 53) chain G residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 54) chain G residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 55) chain G residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3

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