eF-site ID 2qc8-E PDB Code 2qc8 Chain E click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source Homo sapiens (Human) (GLNA_HUMAN) Sequence E:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNET Description Functional site 1) chain E residue 136 type sequence E description BINDING SITE FOR RESIDUE MN E 401 source : BC4 2) chain E residue 196 type sequence E description BINDING SITE FOR RESIDUE MN E 401 source : BC4 3) chain E residue 203 type sequence E description BINDING SITE FOR RESIDUE MN E 401 source : BC4 4) chain E residue 134 type sequence E description BINDING SITE FOR RESIDUE MN E 402 source : BC5 5) chain E residue 253 type sequence H description BINDING SITE FOR RESIDUE MN E 402 source : BC5 6) chain E residue 338 type sequence E description BINDING SITE FOR RESIDUE MN E 402 source : BC5 7) chain E residue 340 type sequence R description BINDING SITE FOR RESIDUE MN E 402 source : BC5 8) chain E residue 134 type sequence E description BINDING SITE FOR RESIDUE MN E 403 source : BC6 9) chain E residue 203 type sequence E description BINDING SITE FOR RESIDUE MN E 403 source : BC6 10) chain E residue 29 type sequence M description BINDING SITE FOR RESIDUE CL A 703 source : DC6 11) chain E residue 44 type sequence T description BINDING SITE FOR RESIDUE CL A 703 source : DC6 12) chain E residue 193 type sequence T description BINDING SITE FOR RESIDUE CL D 704 source : DC7 13) chain E residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S A 601 source : EC6 14) chain E residue 130 type sequence W description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 15) chain E residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 16) chain E residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 17) chain E residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 18) chain E residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 19) chain E residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 20) chain E residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 21) chain E residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 22) chain E residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 23) chain E residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 24) chain E residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 25) chain E residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 26) chain E residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP E 501 source : FC4 27) chain E residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 28) chain E residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 29) chain E residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 30) chain E residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 31) chain E residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 32) chain E residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 33) chain E residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 34) chain E residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 35) chain E residue 306 type sequence T description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 36) chain E residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 37) chain E residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 38) chain E residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 39) chain E residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 40) chain E residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 41) chain E residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 42) chain E residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 43) chain E residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 44) chain E residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 45) chain E residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 46) chain E residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 47) chain E residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 48) chain E residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 49) chain E residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 50) chain E residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 51) chain E residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 52) chain E residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3

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