eF-site ID 2qc8-D PDB Code 2qc8 Chain D click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source Homo sapiens (Human) (GLNA_HUMAN) Sequence D:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETG Description Functional site 1) chain D residue 136 type sequence E description BINDING SITE FOR RESIDUE MN D 401 source : BC1 2) chain D residue 196 type sequence E description BINDING SITE FOR RESIDUE MN D 401 source : BC1 3) chain D residue 203 type sequence E description BINDING SITE FOR RESIDUE MN D 401 source : BC1 4) chain D residue 134 type sequence E description BINDING SITE FOR RESIDUE MN D 402 source : BC2 5) chain D residue 253 type sequence H description BINDING SITE FOR RESIDUE MN D 402 source : BC2 6) chain D residue 338 type sequence E description BINDING SITE FOR RESIDUE MN D 402 source : BC2 7) chain D residue 134 type sequence E description BINDING SITE FOR RESIDUE MN D 403 source : BC3 8) chain D residue 203 type sequence E description BINDING SITE FOR RESIDUE MN D 403 source : BC3 9) chain D residue 193 type sequence T description BINDING SITE FOR RESIDUE CL C 702 source : DC5 10) chain D residue 44 type sequence T description BINDING SITE FOR RESIDUE CL D 704 source : DC7 11) chain D residue 130 type sequence W description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 12) chain D residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 13) chain D residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 14) chain D residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 15) chain D residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 16) chain D residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 17) chain D residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 18) chain D residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 19) chain D residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 20) chain D residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 21) chain D residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 22) chain D residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 23) chain D residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP D 501 source : FC2 24) chain D residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 25) chain D residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 26) chain D residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 27) chain D residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 28) chain D residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 29) chain D residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 30) chain D residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 31) chain D residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 32) chain D residue 306 type sequence T description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 33) chain D residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 34) chain D residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 35) chain D residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S D 601 source : FC3 36) chain D residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S E 601 source : FC5 37) chain D residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 38) chain D residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 39) chain D residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 40) chain D residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 41) chain D residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 42) chain D residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 43) chain D residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 44) chain D residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 45) chain D residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 46) chain D residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 47) chain D residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 48) chain D residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 49) chain D residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 50) chain D residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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