eF-site ID 2iya-B PDB Code 2iya Chain B click to enlarge Title The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering Classification TRANSFERASE Compound OLEANDOMYCIN GLYCOSYLTRANSFERASE Source Streptomyces antibioticus (Q3HTL7_STRAT) Sequence B:  VTPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITD EFAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGL FLDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKW DIPFVQLSPTFVAYEGFEEDVPAVQDPTADGLVRFFTRLS AFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDN YTFVGPTYGDRSWEGRPVLLIALGSAFTDHLDFYRTCLSA VDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQWVPQLDIL TKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAER IVELGLGRHIPRDQVTAEKLREAVLAVASDPGVAERLAAV RQEIREAGGARAAADILEGILAEA Description Functional site 1) chain B residue 24 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 2) chain B residue 27 type sequence N description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 3) chain B residue 242 type sequence R description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 4) chain B residue 263 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 5) chain B residue 264 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 6) chain B residue 290 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 7) chain B residue 312 type sequence W description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 8) chain B residue 313 type sequence V description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 9) chain B residue 315 type sequence Q description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 10) chain B residue 328 type sequence H description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 11) chain B residue 330 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 12) chain B residue 331 type sequence M description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 13) chain B residue 332 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 14) chain B residue 333 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 15) chain B residue 336 type sequence E description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 16) chain B residue 25 type sequence H description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 17) chain B residue 79 type sequence W description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 18) chain B residue 80 type sequence P description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 19) chain B residue 81 type sequence E description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 20) chain B residue 83 type sequence Q description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 21) chain B residue 86 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 22) chain B residue 87 type sequence M description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 23) chain B residue 90 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 24) chain B residue 117 type sequence I description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 25) chain B residue 120 type sequence W description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 26) chain B residue 139 type sequence T description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 27) chain B residue 140 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 28) chain B residue 142 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 29) chain B residue 146 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 30) chain B residue 207 type sequence L description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 31) chain B residue 265 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 32) chain B residue 351 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 33) chain B residue 352 type sequence E description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 34) chain B residue 355 type sequence M description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4

Display surface Download Links