eF-site ID 2iya-AB PDB Code 2iya Chain A, B click to enlarge Title The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering Classification TRANSFERASE Compound OLEANDOMYCIN GLYCOSYLTRANSFERASE Source Streptomyces antibioticus (Q3HTL7_STRAT) Sequence A:  TPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITDE FAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGLF LDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKWD IPFVQLSPTFVAYEGFEEDVPAVQDPTAEDGLVRFFTRLS AFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDN YTFVGPTYGDRSHQGTWEGPGDGRPVLLIALGSAFTDHLD FYRTCLSAVDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQ WVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIA EQTMNAERIVELGLGRHIPRDQVTAEKLREAVLAVASDPG VAERLAAVRQEIREAGGARAAADILEGILAEA B:  VTPRHISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITD EFAAQVKAAGATPVVYDSILPKESNPEESWPEDQESAMGL FLDEAVRVLPQLEDAYADDRPDLIVYDIASWPAPVLGRKW DIPFVQLSPTFVAYEGFEEDVPAVQDPTADGLVRFFTRLS AFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDN YTFVGPTYGDRSWEGRPVLLIALGSAFTDHLDFYRTCLSA VDGLDWHVVLSVGRFVDPADLGEVPPNVEVHQWVPQLDIL TKASAFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAER IVELGLGRHIPRDQVTAEKLREAVLAVASDPGVAERLAAV RQEIREAGGARAAADILEGILAEA Description (1)  OLEANDOMYCIN GLYCOSYLTRANSFERASE (E.C.2.4.1.-) Functional site 1) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 2) chain A residue 27 type sequence N description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 3) chain A residue 242 type sequence R description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 4) chain A residue 245 type sequence Q description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 5) chain A residue 264 type sequence S description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 6) chain A residue 290 type sequence S description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 7) chain A residue 312 type sequence W description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 8) chain A residue 313 type sequence V description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 9) chain A residue 315 type sequence Q description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 10) chain A residue 328 type sequence H description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 11) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 12) chain A residue 331 type sequence M description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 13) chain A residue 332 type sequence G description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 14) chain A residue 333 type sequence S description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 15) chain A residue 336 type sequence E description BINDING SITE FOR RESIDUE UDP A1424 source : AC1 16) chain A residue 25 type sequence H description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 17) chain A residue 79 type sequence W description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 18) chain A residue 80 type sequence P description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 19) chain A residue 83 type sequence Q description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 20) chain A residue 86 type sequence A description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 21) chain A residue 87 type sequence M description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 22) chain A residue 90 type sequence F description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 23) chain A residue 117 type sequence I description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 24) chain A residue 120 type sequence W description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 25) chain A residue 139 type sequence T description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 26) chain A residue 140 type sequence F description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 27) chain A residue 146 type sequence F description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 28) chain A residue 153 type sequence V description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 29) chain A residue 207 type sequence L description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 30) chain A residue 265 type sequence A description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 31) chain A residue 351 type sequence A description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 32) chain A residue 352 type sequence E description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 33) chain A residue 355 type sequence M description BINDING SITE FOR RESIDUE ZIO A1425 source : AC2 34) chain B residue 24 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 35) chain B residue 27 type sequence N description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 36) chain B residue 242 type sequence R description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 37) chain B residue 263 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 38) chain B residue 264 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 39) chain B residue 290 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 40) chain B residue 312 type sequence W description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 41) chain B residue 313 type sequence V description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 42) chain B residue 315 type sequence Q description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 43) chain B residue 328 type sequence H description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 44) chain B residue 330 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 45) chain B residue 331 type sequence M description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 46) chain B residue 332 type sequence G description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 47) chain B residue 333 type sequence S description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 48) chain B residue 336 type sequence E description BINDING SITE FOR RESIDUE UDP B1424 source : AC3 49) chain B residue 25 type sequence H description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 50) chain B residue 79 type sequence W description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 51) chain B residue 80 type sequence P description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 52) chain B residue 81 type sequence E description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 53) chain B residue 83 type sequence Q description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 54) chain B residue 86 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 55) chain B residue 87 type sequence M description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 56) chain B residue 90 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 57) chain B residue 117 type sequence I description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 58) chain B residue 120 type sequence W description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 59) chain B residue 139 type sequence T description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 60) chain B residue 140 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 61) chain B residue 142 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 62) chain B residue 146 type sequence F description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 63) chain B residue 207 type sequence L description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 64) chain B residue 265 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 65) chain B residue 351 type sequence A description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 66) chain B residue 352 type sequence E description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 67) chain B residue 355 type sequence M description BINDING SITE FOR RESIDUE ZIO B1425 source : AC4 68) chain A residue 312-353 type prosite sequence WVPQLDILTKASAFITHAGMGSTMEALSNAVPMVAVPQIA EQ description UDPGT UDP-glycosyltransferases signature. WvpQldILtkas..AFITHAGmgStmeALsnav.PMvavPqiaEQ source prosite : PS00375

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