eF-site ID 2gvg-E PDB Code 2gvg Chain E click to enlarge Title Crystal Structure of human NMPRTase and its complex with NMN Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence E:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain E residue 18 type sequence Y description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 2) chain E residue 391 type sequence T description BINDING SITE FOR RESIDUE PO4 E 608 source : AC8 3) chain E residue 392 type sequence R description BINDING SITE FOR RESIDUE PO4 E 608 source : AC8 4) chain E residue 393 type sequence D description BINDING SITE FOR RESIDUE PO4 E 608 source : AC8 5) chain E residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 6) chain E residue 246 type sequence E description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 7) chain E residue 247 type sequence H description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 8) chain E residue 311 type sequence R description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 9) chain E residue 313 type sequence D description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 10) chain E residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 D 610 source : BC1 11) chain E residue 16 type sequence D description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 12) chain E residue 18 type sequence Y description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 13) chain E residue 392 type sequence R description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 14) chain E residue 193 type sequence F description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 15) chain E residue 196 type sequence R description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 16) chain E residue 219 type sequence D description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 17) chain E residue 311 type sequence R description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 18) chain E residue 313 type sequence D description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 19) chain E residue 353 type sequence G description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 20) chain E residue 354 type sequence D description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 21) chain E residue 384 type sequence G description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 22) chain E residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 23) chain E residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 24) chain E residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 25) chain E residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 26) chain E residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 27) chain E residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 28) chain E residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 29) chain E residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 30) chain E residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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