eF-site ID 2gvg-B PDB Code 2gvg Chain B click to enlarge Title Crystal Structure of human NMPRTase and its complex with NMN Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence B:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain B residue 18 type sequence Y description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 2) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 3) chain B residue 246 type sequence E description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 4) chain B residue 247 type sequence H description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 5) chain B residue 311 type sequence R description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 6) chain B residue 313 type sequence D description BINDING SITE FOR RESIDUE PO4 B 603 source : AC3 7) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 B 604 source : AC4 8) chain B residue 392 type sequence R description BINDING SITE FOR RESIDUE PO4 B 604 source : AC4 9) chain B residue 398 type sequence S description BINDING SITE FOR RESIDUE PO4 B 604 source : AC4 10) chain B residue 400 type sequence K description BINDING SITE FOR RESIDUE PO4 B 604 source : AC4 11) chain B residue 16 type sequence D description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 12) chain B residue 18 type sequence Y description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 13) chain B residue 193 type sequence F description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 14) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 15) chain B residue 219 type sequence D description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 16) chain B residue 311 type sequence R description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 17) chain B residue 313 type sequence D description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 18) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 19) chain B residue 383 type sequence G description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 20) chain B residue 384 type sequence G description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 21) chain B residue 392 type sequence R description BINDING SITE FOR RESIDUE NMN B 502 source : BC5 22) chain B residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 23) chain B residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 24) chain B residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 25) chain B residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 26) chain B residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 27) chain B residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 28) chain B residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 29) chain B residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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