eF-site ID 1xvp-ABCDEFGH PDB Code 1xvp Chain A, B, C, D, E, F, G, H click to enlarge Title crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO Classification DNA BINDING PROTEIN Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (NP_003734) Sequence A:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP B:  PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLF IHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVF RSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPL RYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLL AAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRR PRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPL LQEICS C:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT D:  PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLF IHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVF RSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPL RYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLL AAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRR PRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPL LQEICS E:  HKILHRLLQE F:  RHKILHRLLQEG G:  ERHKILHRLLQE H:  ERHKILHRLLQE Description Functional site 1) chain C residue 268 type sequence I description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 2) chain C residue 272 type sequence A description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 3) chain C residue 275 type sequence Q description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 4) chain C residue 313 type sequence F description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 5) chain C residue 316 type sequence R description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 6) chain C residue 326 type sequence L description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 7) chain C residue 327 type sequence A description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 8) chain C residue 345 type sequence I description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 9) chain C residue 432 type sequence C description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 10) chain A residue 272 type sequence A description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 11) chain A residue 275 type sequence Q description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 12) chain A residue 313 type sequence F description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 13) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 14) chain A residue 327 type sequence A description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 15) chain A residue 345 type sequence I description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 16) chain A residue 432 type sequence C description BINDING SITE FOR RESIDUE F15 A 1002 source : AC2 17) chain D residue 161 type sequence F description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 18) chain D residue 165 type sequence N description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 19) chain D residue 168 type sequence M description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 20) chain D residue 199 type sequence V description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 21) chain D residue 203 type sequence H description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 22) chain D residue 206 type sequence L description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 23) chain D residue 217 type sequence F description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 24) chain D residue 224 type sequence Y description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 25) chain D residue 225 type sequence T description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 26) chain D residue 228 type sequence D description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 27) chain D residue 229 type sequence G description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 28) chain D residue 239 type sequence L description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 29) chain D residue 242 type sequence L description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 30) chain D residue 243 type sequence F description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 31) chain D residue 326 type sequence Y description BINDING SITE FOR RESIDUE CID D 1003 source : AC3 32) chain A residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 34) chain C residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 35) chain C residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 259 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 37) chain C residue 259 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3 39) chain C residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links