eF-site ID 1t7d-A
PDB Code 1t7d
Chain A

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Title Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor
Classification HYDROLASE/ANTIBIOTIC
Compound SIGNAL PEPTIDASE I
Source ORGANISM_SCIENTIFIC: STREPTOMYCES TU;
Sequence A:  IYEPFQIPSGSMMPTLLIGDFILVEKFHPKRGDIVVFKYP
EDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCNALPVT
YSNVEPSDFVQTFSRREATSGFFEVPKNETKENGIRLSER
KETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPG
QYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDLR
LSRIGGIH
Description


Functional site

1) chain A
residue 82
type
sequence E
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

2) chain A
residue 83
type
sequence P
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

3) chain A
residue 85
type
sequence Q
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

4) chain A
residue 87
type
sequence P
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

5) chain A
residue 90
type
sequence S
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

6) chain A
residue 142
type
sequence D
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

7) chain A
residue 143
type
sequence Y
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

8) chain A
residue 144
type
sequence I
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

9) chain A
residue 145
type
sequence K
description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2
source : AC1

10) chain A
residue 88
type catalytic
sequence S
description 635
source MCSA : MCSA1

11) chain A
residue 90
type catalytic
sequence S
description 635
source MCSA : MCSA1

12) chain A
residue 145
type catalytic
sequence K
description 635
source MCSA : MCSA1

13) chain A
residue 278
type catalytic
sequence S
description 635
source MCSA : MCSA1

14) chain A
residue 88-95
type prosite
sequence SGSMMPTL
description SPASE_I_1 Signal peptidases I serine active site. SGSMMPTL
source prosite : PS00501

15) chain A
residue 145-157
type prosite
sequence KRAVGLPGDKVTY
description SPASE_I_2 Signal peptidases I lysine active site. KRAVGlPGDkVtY
source prosite : PS00760

16) chain A
residue 268-281
type prosite
sequence YFMMGDNRDNSADS
description SPASE_I_3 Signal peptidases I signature 3. YFMMGDNRdnSadS
source prosite : PS00761

17) chain A
residue 90
type ACT_SITE
sequence S
description
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 145
type ACT_SITE
sequence K
description
source Swiss-Prot : SWS_FT_FI2


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