eF-site ID 1qpe-A PDB Code 1qpe Chain A click to enlarge Title STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS Classification TRANSFERASE Compound LCK KINASE Source Homo sapiens (Human) (LCK_HUMAN) Sequence A:  KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE DNEXTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILL TEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELY QLMRLCWKERPEDRPTFDYLRSVLEDFFTAT Description (1)  LCK KINASE (E.C.2.7.1.112) Functional site 1) chain A residue 298 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 2) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 3) chain A residue 377 type sequence S description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 4) chain A residue 379 type sequence K description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 5) chain A residue 457 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 6) chain A residue 458 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 7) chain A residue 474 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 8) chain A residue 330 type sequence T description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 9) chain A residue 331 type sequence P description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 10) chain A residue 332 type sequence S description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 11) chain A residue 358 type sequence R description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 12) chain A residue 409 type sequence P description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 13) chain A residue 413 type sequence N description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 14) chain A residue 450 type sequence I description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 15) chain A residue 453 type sequence L description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 16) chain A residue 454 type sequence E description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 17) chain A residue 251 type sequence L description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 18) chain A residue 259 type sequence V description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 19) chain A residue 271 type sequence A description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 20) chain A residue 288 type sequence E description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 21) chain A residue 314 type sequence I description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 22) chain A residue 316 type sequence T description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 23) chain A residue 317 type sequence E description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 24) chain A residue 319 type sequence M description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 25) chain A residue 371 type sequence L description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 26) chain A residue 382 type sequence D description BINDING SITE FOR RESIDUE PP2 A 1904 source : AC4 27) chain A residue 251-273 type prosite sequence LGAGQFGEVWMGYYNGHTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmGyynghtk...........VAVK source prosite : PS00107 28) chain A residue 360-372 type prosite sequence YIHRDLRAANILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANILV source prosite : PS00109 29) chain A residue 365 type ACT_SITE sequence L description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 252 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 274 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 395 type MOD_RES sequence T description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8139546 source Swiss-Prot : SWS_FT_FI3

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