eF-site ID 1pyx-B PDB Code 1pyx Chain B click to enlarge Title GSK-3 Beta complexed with AMP-PNP Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence B:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC DFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE QIREMFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP TARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQ ELSSNPPLATILIPPHAR Description Functional site 1) chain B residue 186 type sequence N description BINDING SITE FOR RESIDUE MG B 2002 source : AC3 2) chain B residue 200 type sequence D description BINDING SITE FOR RESIDUE MG B 2002 source : AC3 3) chain B residue 200 type sequence D description BINDING SITE FOR RESIDUE MG B 2003 source : AC4 4) chain B residue 64 type sequence N description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 5) chain B residue 65 type sequence G description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 6) chain B residue 70 type sequence V description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 7) chain B residue 83 type sequence A description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 8) chain B residue 85 type sequence K description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 9) chain B residue 110 type sequence V description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 10) chain B residue 133 type sequence D description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 11) chain B residue 134 type sequence Y description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 12) chain B residue 135 type sequence V description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 13) chain B residue 138 type sequence T description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 14) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 15) chain B residue 183 type sequence K description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 16) chain B residue 185 type sequence Q description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 17) chain B residue 186 type sequence N description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 18) chain B residue 188 type sequence L description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 19) chain B residue 200 type sequence D description BINDING SITE FOR RESIDUE ANP B 2001 source : AC6 20) chain B residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 21) chain B residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI5

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