eF-site ID 1pyx-A PDB Code 1pyx Chain A click to enlarge Title GSK-3 Beta complexed with AMP-PNP Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence A:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC DFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE QIREMNPFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEY TPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFT TQELSSNPPLATILIPPHARIQA Description Functional site 1) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE MG A 1002 source : AC1 2) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE MG A 1002 source : AC1 3) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE MG A 1003 source : AC2 4) chain A residue 62 type sequence I description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 5) chain A residue 63 type sequence G description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 6) chain A residue 64 type sequence N description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 7) chain A residue 65 type sequence G description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 8) chain A residue 70 type sequence V description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 9) chain A residue 83 type sequence A description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 10) chain A residue 85 type sequence K description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 11) chain A residue 110 type sequence V description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 12) chain A residue 133 type sequence D description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 13) chain A residue 134 type sequence Y description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 14) chain A residue 135 type sequence V description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 15) chain A residue 138 type sequence T description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 16) chain A residue 181 type sequence D description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 17) chain A residue 183 type sequence K description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 18) chain A residue 185 type sequence Q description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 19) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 20) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 21) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE ANP A 1001 source : AC5 22) chain A residue 62-86 type prosite sequence IGNGSFGVVYQAKLCDSGELVAIKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK source prosite : PS00107 23) chain A residue 177-189 type prosite sequence ICHRDIKPQNLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL source prosite : PS00108 24) chain A residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 25) chain A residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI5

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