eF-site ID 1mtb-B PDB Code 1mtb Chain B click to enlarge Title Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence B:  PQITLWQRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE QNC A 100 source : AC1 2) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE HPH A 102 source : AC3 3) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE HPH A 102 source : AC3 4) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE DIQ B 100 source : AC4 5) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE DIQ B 100 source : AC4 6) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE NTB B 101 source : AC5 7) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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