1MTB

Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy

Summary for 1MTB

• Entry DOI: 10.2210/pdb1mtb/pdb
• Related: 1F7A 1HXB 1MT7 1MT8 1MT9
• Descriptor: PROTEASE RETROPEPSIN, quinoline-2-carboxylic acid, ASPARAGINE, ... (7 entities in total)
• Functional Keywords: hiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22342.36

Authors

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (deposition date: 2002-09-20, release date: 2003-01-07, Last modification date: 2024-03-13)

• Primary citation: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy; J.Virol., 77:1305-1315, 2003; PubMed: 12502847; DOI: 10.1128/JVI.77.2.1306-1315.2003

Experimental method

X-RAY DIFFRACTION (2.5 Å)