eF-site ID 1lf2-A PDB Code 1lf2 Chain A click to enlarge Title CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370 Classification HYDROLASE Compound Plasmepsin 2 Source Plasmodium falciparum (PLM2_PLAFA) Sequence A:  SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANL WVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSG TVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTF DGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPV HDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAH VGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVP FLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDV GPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSV GIALAKKNL Description Functional site 1) chain A residue 34 type sequence D description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 2) chain A residue 36 type sequence G description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 3) chain A residue 76 type sequence N description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 4) chain A residue 77 type sequence Y description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 5) chain A residue 78 type sequence V description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 6) chain A residue 79 type sequence S description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 7) chain A residue 111 type sequence F description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 8) chain A residue 123 type sequence I description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 9) chain A residue 131 type sequence L description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 10) chain A residue 192 type sequence Y description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 11) chain A residue 214 type sequence D description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 12) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 13) chain A residue 217 type sequence T description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 14) chain A residue 218 type sequence S description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 15) chain A residue 240 type sequence P description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 16) chain A residue 241 type sequence F description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 17) chain A residue 294 type sequence F description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 18) chain A residue 295 type sequence P description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 19) chain A residue 296 type sequence V description BINDING SITE FOR RESIDUE R37 A 330 source : AC1 20) chain A residue 31-42 type prosite sequence FILDTGSANLWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FILDTGSANLWV source prosite : PS00141 21) chain A residue 211-222 type prosite sequence CIVDSGTSAITV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FILDTGSANLWV source prosite : PS00141 22) chain A residue 34 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 214 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1

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