eF-site ID 1kz7-ABCD PDB Code 1kz7 Chain A, B, C, D click to enlarge Title Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 Classification SIGNALING PROTEIN Compound GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS Source Mus musculus (Mouse) (CDC42_HUMAN) Sequence A:  EEEESLAILRRHVXNELLDTERAYVEELLCVLEGYAAEXD NPLXAHLISTGLQNKKNILFGNXEEIYHFHNRIFLRELES CIDCPELVGRCFLERXEEFQIYEKYCQNKPRSESLWRQCS DCPFFQECQKKLDHKLSLDSYLLKPVQRITKYQLLLKEXL KYSKHCEGAEDLQEALSSILGILKAVNDSXHLIAITGYDG NLGDLGKLLXQGSFSVWTDHKKGELARFKPXQRHLFLHEK AVLFCKKREENGEGYEKAPSYSYKQSLNXTAVGITENVKG DTKKFEIWYNAREEVYIIQAPTPEIKAAWVNAIRKVLTSQ LQACREASQHRALEQSH B:  MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNY AVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLV CFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL TQKGLKNVFDEAILAALEPPEPKKSRRS C:  EEEESLAILRRHVXNELLDTERAYVEELLCVLEGYAAEXD NPLXAHLISTGLQNKKNILFGNXEEIYHFHNRIFLRELES CIDCPELVGRCFLERXEEFQIYEKYCQNKPRSESLWRQCS DCPFFQECQKKLDHKLSLDSYLLKPVQRITKYQLLLKEXL KYSKHCEGAEDLQEALSSILGILKAVNDSXHLIAITGYDG NLGDLGKLLXQGSFSVWTDHKELARFKPXQRHLFLHEKAV LFCKKREENGEGYEKAPSYSYKQSLNXTAVGITENVKGDT KKFEIWYNAREEVYIIQAPTPEIKAAWVNAIRKVLTSQLQ ACREASQHRA D:  MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNY AVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLV CFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL TQKGLKNVFDEAILAAL Description Functional site 1) chain B residue 10 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 2) chain B residue 115 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1 3) chain D residue 1010 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 4) chain D residue 1115 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1 5) chain B residue 57 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 6) chain D residue 1057 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 source Swiss-Prot : SWS_FT_FI9 8) chain D residue 1035 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 source Swiss-Prot : SWS_FT_FI9 9) chain B residue 188 type MOD_RES sequence S description Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA source Swiss-Prot : SWS_FT_FI6 10) chain B residue 188 type LIPID sequence S description S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA source Swiss-Prot : SWS_FT_FI7 11) chain B residue 32 type CARBOHYD sequence Y description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8 12) chain D residue 1032 type CARBOHYD sequence Y description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8 13) chain A residue 761-786 type prosite sequence LDSYLLKPVQRITKYQLLLKEXLKYS description DH_1 Dbl homology (DH) domain signature. LdsYLlkPVqrItKyqLlLkEMlkyS source prosite : PS00741 14) chain B residue 32 type MOD_RES sequence Y description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875 source Swiss-Prot : SWS_FT_FI3 15) chain D residue 1032 type MOD_RES sequence Y description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 35 type MOD_RES sequence T description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 source Swiss-Prot : SWS_FT_FI4 17) chain D residue 1035 type MOD_RES sequence T description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 64 type MOD_RES sequence Y description Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284 source Swiss-Prot : SWS_FT_FI5 19) chain D residue 1064 type MOD_RES sequence Y description Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284 source Swiss-Prot : SWS_FT_FI5

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