eF-site ID 1kv5-AB PDB Code 1kv5 Chain A, B click to enlarge Title Structure of Trypanosoma brucei brucei TIM with the salt-bridge-forming residue Arg191 mutated to Ser Classification ISOMERASE Compound triosephosphate isomerase, glycosomal Source Trypanosoma brucei brucei (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALISSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALISSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 2) chain A residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 3) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 4) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 5) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 6) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 7) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 8) chain A residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 9) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 10) chain A residue 232 type sequence L description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 11) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 12) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 13) chain B residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 14) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 15) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 16) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 17) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 18) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 19) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 20) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 21) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 22) chain B residue 232 type sequence L description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 23) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 24) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA B 2350 source : AC2 25) chain B residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 26) chain B residue 33 type sequence I description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 27) chain B residue 34 type sequence N description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 28) chain B residue 35 type sequence H description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 29) chain B residue 247 type sequence K description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 30) chain B residue 250 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 5600 source : AC3 31) chain A residue 144 type sequence L description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 32) chain A residue 193 type sequence W description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 33) chain B residue 148 type sequence A description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 34) chain B residue 193 type sequence W description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 35) chain B residue 197 type sequence K description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 36) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE GOL A 4500 source : AC5 37) chain A residue 156 type sequence K description BINDING SITE FOR RESIDUE GOL A 4500 source : AC5 38) chain B residue 176 type sequence K description BINDING SITE FOR RESIDUE GOL B 4501 source : AC6 39) chain B residue 182 type sequence Q description BINDING SITE FOR RESIDUE GOL B 4501 source : AC6 40) chain B residue 38 type sequence Q description BINDING SITE FOR RESIDUE GOL B 4502 source : AC7 41) chain B residue 89 type sequence N description BINDING SITE FOR RESIDUE GOL B 4502 source : AC7 42) chain B residue 90 type sequence W description BINDING SITE FOR RESIDUE GOL B 4502 source : AC7 43) chain A residue 181 type sequence Q description BINDING SITE FOR RESIDUE GOL A 4503 source : AC8 44) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE GOL A 4503 source : AC8 45) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 46) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 47) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 48) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 49) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 50) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 51) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 52) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 53) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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