|
|
eF-site ID
|
1k3b-C |
|
PDB Code
|
1k3b |
|
Chain
|
C |
|
click to enlarge
|
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Title
|
Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases |
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Classification
|
HYDROLASE |
|
Compound
|
dipeptydil-peptidase I exclusion domain |
|
Source
|
(CATC_HUMAN) |
|
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Sequence
|
C: |
DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWG
ENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
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Description
|
(1) |
dipeptydil-peptidase I exclusion domain/light chain/heavy chain (E.C.3.4.14.1)
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
379-389 |
| type |
prosite |
| sequence |
TNHAVLLVGYG
|
| description |
THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. TNHAVLLVGYG
|
| source |
prosite : PS00639
|
|
|
2)
|
chain |
C |
| residue |
398-417 |
| type |
prosite |
| sequence |
YWIVKNSWGTGWGENGYFRI
|
| description |
THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgtgWGenGYFrI
|
| source |
prosite : PS00640
|
|
|
3)
|
chain |
C |
| residue |
381 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
C |
| residue |
403 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|