|
|
eF-site ID
|
1k3b-B |
|
PDB Code
|
1k3b |
|
Chain
|
B |
|
click to enlarge
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Title
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Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases |
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Classification
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HYDROLASE |
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Compound
|
dipeptydil-peptidase I exclusion domain |
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Source
|
(CATC_HUMAN) |
|
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Sequence
|
B: |
LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEAR
IRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY
AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG
FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH
TGLR
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Description
|
(1) |
dipeptydil-peptidase I exclusion domain/light chain/heavy chain (E.C.3.4.14.1)
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
228-239 |
| type |
prosite |
| sequence |
QASCGSCYSFAS
|
| description |
THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS
|
| source |
prosite : PS00139
|
|
|
2)
|
chain |
B |
| residue |
280 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
323 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
252 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|