eF-site ID 1k3b-B
PDB Code 1k3b
Chain B

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Title Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases
Classification HYDROLASE
Compound dipeptydil-peptidase I exclusion domain
Source (CATC_HUMAN)
Sequence B:  LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEAR
IRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY
AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG
FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH
TGLR
Description (1)  dipeptydil-peptidase I exclusion domain/light chain/heavy chain (E.C.3.4.14.1)


Functional site

1) chain B
residue 228-239
type prosite
sequence QASCGSCYSFAS
description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS
source prosite : PS00139

2) chain B
residue 280
type ACT_SITE
sequence Y
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
source Swiss-Prot : SWS_FT_FI2

3) chain B
residue 323
type ACT_SITE
sequence Y
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
source Swiss-Prot : SWS_FT_FI2

4) chain B
residue 252
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329
source Swiss-Prot : SWS_FT_FI3


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