|
eF-site ID
|
1k3b-B |
PDB Code
|
1k3b |
Chain
|
B |
|
click to enlarge
|
|
Title
|
Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases |
Classification
|
HYDROLASE |
Compound
|
dipeptydil-peptidase I exclusion domain |
Source
|
(CATC_HUMAN) |
|
Sequence
|
B: |
LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEAR
IRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY
AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG
FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH
TGLR
|
|
Description
|
(1) |
dipeptydil-peptidase I exclusion domain/light chain/heavy chain (E.C.3.4.14.1)
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
228-239 |
type |
prosite |
sequence |
QASCGSCYSFAS
|
description |
THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS
|
source |
prosite : PS00139
|
|
2)
|
chain |
B |
residue |
280 |
type |
ACT_SITE |
sequence |
Y
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
B |
residue |
323 |
type |
ACT_SITE |
sequence |
Y
|
description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
252 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|