eF-site ID 1g6i-A PDB Code 1g6i Chain A click to enlarge Title Crystal structure of the yeast alpha-1,2-mannosidase with bound 1-deoxymannojirimycin at 1.59 A resolution Classification HYDROLASE Compound CLASS I ALPHA-1,2-MANNOSIDASE Source (MNS1_YEAST) Sequence A:  AGEMDRDRIESMFLESWRDYSKHGWGYDVYGPIEHTSHNM PRGNQPLGWIIVDSVDTLMLMYNSSTLYKSEFEAEIQRSE HWINDVLDFDIDAEVNVFETTIRMLGGLLSAYHLSDVLEV GNKTVYLNKAIDLGDRLALAFLSTQTGIPYSSINLHSGQA VKNHADGGASSTAEFTTLQMEFKYLAYLTGNRTYWELVER VYEPLYKNNDLLNTYDGLVPIYTFPDTGKFGASTIRFGSR GDSFYEYLLKQYLLTHETLYYDLYRKSMEGMKKHLLAQSK PSSLWYIGEREQGLQGQLSPKMDHLVCFMGGLLASGSTEG LSIHEARRRPFFSKSDWDLAKGITDTCYQMYKQSSSGLAP EIVVFNDGNIKDGWWRSSVGDFFVKPLDRHNLQRPETVES IMFMYHLSHDHKYREWGAEIATSFFENTCVDCNDPKLRRF TSLSDCITLPTKKSNNMESFWLAETLKYLYILFLDEFDLT KVVFNTEAHPFPVLDEEILKSQSLTTGWSL Description Functional site 1) chain A residue 132 type catalytic sequence E description 19 source MCSA : MCSA1 2) chain A residue 136 type catalytic sequence R description 19 source MCSA : MCSA1 3) chain A residue 275 type catalytic sequence D description 19 source MCSA : MCSA1 4) chain A residue 440 type catalytic sequence I description 19 source MCSA : MCSA1 5) chain A residue 404 type ACT_SITE sequence N description Proton donor => ECO:0000250|UniProtKB:P31723 source Swiss-Prot : SWS_FT_FI4 6) chain A residue 530 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10675327 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 96 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.7, ECO:0007744|PDB:1G6I source Swiss-Prot : SWS_FT_FI6 8) chain A residue 155 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.7, ECO:0007744|PDB:1G6I source Swiss-Prot : SWS_FT_FI6 9) chain A residue 224 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.7, ECO:0007744|PDB:1G6I source Swiss-Prot : SWS_FT_FI6

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