登録情報 データベース : EMDB / ID : EMD-19496 ダウンロードとリンクタイトル Structure of the formin Cdc12 bound to the barbed end of phalloidin-stabilized F-actin. マップデータSharpened, local-resolution filtered cryo-EM density map of the formin Cdc12 bound to the barbed end of phalloidin-stabilized F-actin. 詳細 試料複合体 : Complex of the dimeric FH2 domain of S. Pombe Cdc12 bound to the barbed end of phalloidin stabilized F-actin.複合体 : Actin filament マイクロフィラメントタンパク質・ペプチド : Actin, cytoplasmic 1, N-terminally processed アクチン複合体 : Dimeric FH2 domain of S. Pombe Cdc12タンパク質・ペプチド : Cell division control protein 12複合体 : Phalloidin.タンパク質・ペプチド : Phalloidinリガンド : ADENOSINE-5'-DIPHOSPHATEリガンド : MAGNESIUM IONリガンド : PHOSPHATE ION リン酸塩 詳細 キーワード actin (アクチン) / formin / Cdc12 / actin assembly. (アクチン) / STRUCTURAL PROTEIN (タンパク質)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
F-bar domain binding / protein localization to mitotic actomyosin contractile ring / medial cortical node / mitotic actomyosin contractile ring, proximal layer / mitotic actomyosin contractile ring / medial cortex / mitotic actomyosin contractile ring assembly / positive regulation of norepinephrine uptake / cellular response to cytochalasin B / bBAF complex ... F-bar domain binding / protein localization to mitotic actomyosin contractile ring / medial cortical node / mitotic actomyosin contractile ring, proximal layer / mitotic actomyosin contractile ring / medial cortex / mitotic actomyosin contractile ring assembly / positive regulation of norepinephrine uptake / cellular response to cytochalasin B / bBAF complex / npBAF complex / postsynaptic actin cytoskeleton organization / regulation of transepithelial transport / brahma complex / nBAF complex / structural constituent of postsynaptic actin cytoskeleton / morphogenesis of a polarized epithelium / GBAF complex / postsynaptic actin cytoskeleton / protein localization to adherens junction / Formation of annular gap junctions / regulation of G0 to G1 transition / dense body / Gap junction degradation / Tat protein binding / Cell-extracellular matrix interactions / Folding of actin by CCT/TriC / regulation of double-strand break repair / regulation of nucleotide-excision repair / RSC-type complex / apical protein localization / mating projection tip / barbed-end actin filament capping / Prefoldin mediated transfer of substrate to CCT/TriC / adherens junction assembly / RHOF GTPase cycle / Adherens junctions interactions / 密着結合 / Sensory processing of sound by outer hair cells of the cochlea / SWI/SNF complex / Interaction between L1 and Ankyrins / Sensory processing of sound by inner hair cells of the cochlea / regulation of mitotic metaphase/anaphase transition / regulation of norepinephrine uptake / positive regulation of double-strand break repair / positive regulation of T cell differentiation / NuA4 histone acetyltransferase complex / regulation of synaptic vesicle endocytosis / apical junction complex / establishment or maintenance of cell polarity / cell division site / maintenance of blood-brain barrier / positive regulation of stem cell population maintenance / positive regulation of double-strand break repair via homologous recombination / cortical cytoskeleton / nitric-oxide synthase binding / regulation of cyclin-dependent protein serine/threonine kinase activity / Recycling pathway of L1 / regulation of G1/S transition of mitotic cell cycle / actin filament bundle assembly / negative regulation of cell differentiation / 刷子縁 / kinesin binding / ヘルト萼状シナプス / EPH-ephrin mediated repulsion of cells / RHO GTPases Activate WASPs and WAVEs / RHO GTPases activate IQGAPs / positive regulation of myoblast differentiation / regulation of protein localization to plasma membrane / EPHB-mediated forward signaling / substantia nigra development / actin filament polymerization / 軸索誘導 / negative regulation of protein binding / 運動性 / マイクロフィラメント / Translocation of SLC2A4 (GLUT4) to the plasma membrane / RHO GTPases Activate Formins / regulation of transmembrane transporter activity / positive regulation of cell differentiation / FCGR3A-mediated phagocytosis / 接着結合 / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / DNA Damage Recognition in GG-NER / Signaling by high-kinase activity BRAF mutants / Schaffer collateral - CA1 synapse / MAP2K and MAPK activation / tau protein binding / B-WICH complex positively regulates rRNA expression / structural constituent of cytoskeleton / cytoplasmic ribonucleoprotein granule / 動原体 / Regulation of actin dynamics for phagocytic cup formation / 血小板 / small GTPase binding / nuclear matrix / VEGFA-VEGFR2 Pathway / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF 類似検索 - 分子機能 Formin, FH3 domain / Formin, GTPase-binding domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain profile. / Formin, FH2 domain / Formin, FH2 domain superfamily ... Formin, FH3 domain / Formin, GTPase-binding domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Diaphanous FH3 Domain / Diaphanous GTPase-binding Domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain / Rho GTPase-binding/formin homology 3 (GBD/FH3) domain profile. / Formin, FH2 domain / Formin, FH2 domain superfamily / Formin Homology 2 Domain / Formin homology-2 (FH2) domain profile. / Formin Homology 2 Domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / アクチン / Actin family / アクチン / ATPase, nucleotide binding domain / Armadillo-like helical / Armadillo-type fold 類似検索 - ドメイン・相同性 Actin, cytoplasmic 1 / Cell division control protein 12 類似検索 - 構成要素生物種 Homo sapiens (ヒト) / Schizosaccharomyces pombe (分裂酵母) / Amanita phalloides (タマゴテングタケ)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.56 Å 詳細 データ登録者Oosterheert W / Boiero Sanders M / Funk J / Prumbaum D / Raunser S / Bieling P 資金援助 ドイツ, European Union, 3件 詳細 詳細を隠すOrganization Grant number 国 Alexander von Humboldt Foundation ドイツ German Research Foundation (DFG) BI 1998/2-1 ドイツ European Research Council (ERC) 856118 European Union
引用ジャーナル : To Be Published タイトル : Mechanism of formin-mediated processive elongation of actin filaments revealed by cryo-EM著者 : Oosterheert W / Boiero Sanders M / Funk J / Prumbaum D / Raunser S / Bieling P 履歴 登録 2024年1月29日 - ヘッダ(付随情報) 公開 2024年4月10日 - マップ公開 2024年4月10日 - 更新 2024年4月10日 - 現状 2024年4月10日 処理サイト : PDBe / 状態 : 公開
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