登録情報 | データベース: PDB / ID: 8se6 |
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タイトル | NKG2D complexed with inhibitor 36 |
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要素 | NKG2-D type II integral membrane protein |
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キーワード | IMMUNE SYSTEM/INHIBITOR / NKG2D / DEL / cryptic pocket / immunoreceptors / Immune System / SIGNALING PROTEIN / IMMUNE SYSTEM-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
negative regulation of natural killer cell chemotaxis / MHC class Ib receptor activity / positive regulation of natural killer cell mediated cytotoxicity / natural killer cell activation / negative regulation of GTPase activity / natural killer cell mediated cytotoxicity / MHC class I protein binding / stimulatory C-type lectin receptor signaling pathway / nitric oxide biosynthetic process / T cell costimulation ...negative regulation of natural killer cell chemotaxis / MHC class Ib receptor activity / positive regulation of natural killer cell mediated cytotoxicity / natural killer cell activation / negative regulation of GTPase activity / natural killer cell mediated cytotoxicity / MHC class I protein binding / stimulatory C-type lectin receptor signaling pathway / nitric oxide biosynthetic process / T cell costimulation / DAP12 interactions / positive regulation of type II interferon production / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of nitric oxide biosynthetic process / DAP12 signaling / signaling receptor activity / carbohydrate binding / cellular response to lipopolysaccharide / adaptive immune response / cell differentiation / defense response to Gram-positive bacterium / external side of plasma membrane / cell surface / signal transduction / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 NKG2-D type II integral membrane protein / Natural killer cell receptor-like, C-type lectin-like domain / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold類似検索 - ドメイン・相同性 TRIETHYLENE GLYCOL / Chem-ZWA / NKG2-D type II integral membrane protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.36 Å |
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データ登録者 | Thompson, A.A. / Grant, J.C. / Karpowich, N.K. / Sharma, S. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Other private | | 米国 |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2023 タイトル: Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D). 著者: Wang, J. / Nakafuku, K.M. / Ziff, J. / Gelin, C.F. / Gholami, H. / Thompson, A.A. / Karpowich, N.K. / Limon, L. / Coate, H.R. / Damm-Ganamet, K.L. / Shih, A.Y. / Grant, J.C. / Cote, M. / Mak, ...著者: Wang, J. / Nakafuku, K.M. / Ziff, J. / Gelin, C.F. / Gholami, H. / Thompson, A.A. / Karpowich, N.K. / Limon, L. / Coate, H.R. / Damm-Ganamet, K.L. / Shih, A.Y. / Grant, J.C. / Cote, M. / Mak, P.A. / Pascual, H.A. / Rives, M.L. / Edwards, J.P. / Venable, J.D. / Venkatesan, H. / Shi, Z. / Allen, S.J. / Sharma, S. / Kung, P.P. / Shireman, B.T. |
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履歴 | 登録 | 2023年4月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年10月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月1日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume |
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