Entry Database : PDB / ID : 8cjh Structure visualization Downloads & linksTitle Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin ComponentsColibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK Details Keywords BIOSYNTHETIC PROTEIN / polyketide Synthase / ketosynthase domain / Acyltransferase domain / Acyl Carrier Protein domainFunction / homology Function and homology informationFunction Domain/homology Component
small molecule metabolic process / : / acyltransferase activity / phosphopantetheine binding / ligase activity / oxidoreductase activity / cytoplasm Similarity search - Function Nitroreductase / Nitroreductase family / Nitroreductase-like / Condensation domain / Condensation domain / Amino acid adenylation domain / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / ANL, N-terminal domain / AMP-binding, conserved site ... Nitroreductase / Nitroreductase family / Nitroreductase-like / Condensation domain / Condensation domain / Amino acid adenylation domain / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / ANL, N-terminal domain / AMP-binding, conserved site / Chloramphenicol acetyltransferase-like domain superfamily / Putative AMP-binding domain signature. / Polyketide synthase, phosphopantetheine-binding domain / Phosphopantetheine attachment site / AMP-dependent synthetase/ligase / AMP-binding enzyme, C-terminal domain superfamily / AMP-binding enzyme / Beta-ketoacyl synthase / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain / Thiolase-like / Phosphopantetheine attachment site / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.982 Å DetailsAuthors Bonhomme, S. / Dessen, A. / Macheboeuf, P. Funding support France, 2items Details Hide detailsOrganization Grant number Country Other government M32917 France Other government AO12-20 France
CitationJournal : Structure / Year : 2023Title : Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin.Authors : Bonhomme, S. / Contreras-Martel, C. / Dessen, A. / Macheboeuf, P. History Deposition Feb 13, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 26, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Jun 14, 2023 Group : Database references / Refinement description / Category : citation / struct_ncs_dom / struct_ncs_dom_limItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _struct_ncs_dom.details / _struct_ncs_dom_lim.beg_auth_asym_id / _struct_ncs_dom_lim.end_auth_asym_id
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