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Yorodumi- PDB-7x4i: Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7x4i | |||||||||
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Title | Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD | |||||||||
Components |
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Keywords | ANTIVIRAL PROTEIN / Nanobody / SARS-CoV-1 / RBD | |||||||||
Function / homology | Function and homology information : / endocytosis involved in viral entry into host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / membrane => GO:0016020 / receptor-mediated virion attachment to host cell / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / host cell plasma membrane / virion membrane Similarity search - Function | |||||||||
Biological species | Severe acute respiratory syndrome coronavirus Vicugna pacos (alpaca) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.38 Å | |||||||||
Authors | Ma, H. / Zeng, W.H. / Jin, T.C. | |||||||||
Funding support | China, 2items
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Citation | Journal: Cell Discov / Year: 2022 Title: A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration. Authors: Ma, H. / Zhang, X. / Zeng, W. / Zhou, J. / Chi, X. / Chen, S. / Zheng, P. / Wang, M. / Wu, Y. / Zhao, D. / Gong, F. / Lin, H. / Sun, H. / Yu, C. / Shi, Z. / Hu, X. / Zhang, H. / Jin, T. / Chiu, S. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7x4i.cif.gz | 486.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7x4i.ent.gz | 405.1 KB | Display | PDB format |
PDBx/mmJSON format | 7x4i.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/x4/7x4i ftp://data.pdbj.org/pub/pdb/validation_reports/x4/7x4i | HTTPS FTP |
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-Related structure data
Related structure data | 70lzS 7lm9S S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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