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-基本情報
登録情報 | データベース: PDB / ID: 7tvf | ||||||
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タイトル | Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom | ||||||
要素 |
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キーワード | SIGNALING PROTEIN / Oncoprotein Phosphatase Scaffold protein Adaptor RAS Leucine rich repeat | ||||||
機能・相同性 | 機能・相同性情報 cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / グリコーゲン / regulation of glycogen biosynthetic process / GTP-dependent protein binding / nerve growth factor signaling pathway / protein phosphatase 1 binding ...cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / グリコーゲン / regulation of glycogen biosynthetic process / GTP-dependent protein binding / nerve growth factor signaling pathway / protein phosphatase 1 binding / protein phosphatase regulator activity / cadherin binding involved in cell-cell adhesion / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of Ras protein signal transduction / regulation of canonical Wnt signaling pathway / regulation of translational initiation / myosin phosphatase activity / branching morphogenesis of an epithelial tube / protein serine/threonine phosphatase activity / glycogen metabolic process / protein-serine/threonine phosphatase / Triglyceride catabolism / entrainment of circadian clock by photoperiod / phosphatase activity / phosphoprotein phosphatase activity / DARPP-32 events / negative regulation of neuron differentiation / fibroblast growth factor receptor signaling pathway / ribonucleoprotein complex binding / 脱リン酸化 / positive regulation of neuron differentiation / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / 低分子量GTPアーゼ / G protein activity / cellular response to leukemia inhibitory factor / response to lead ion / 接着結合 / RAF activation / circadian regulation of gene expression / lung development / regulation of circadian rhythm / positive regulation of neuron projection development / GDP binding / Circadian Clock / presynapse / actin cytoskeleton organization / perikaryon / protein phosphatase binding / Ras protein signal transduction / 樹状突起スパイン / 細胞周期 / 細胞分裂 / GTPase activity / glutamatergic synapse / 核小体 / GTP binding / シグナル伝達 / extracellular exosome / 核質 / metal ion binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.17 Å | ||||||
データ登録者 | Bonsor, D.A. / Simanshu, D.K. | ||||||
資金援助 | 米国, 1件
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2022 タイトル: Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. 著者: Bonsor, D.A. / Alexander, P. / Snead, K. / Hartig, N. / Drew, M. / Messing, S. / Finci, L.I. / Nissley, D.V. / McCormick, F. / Esposito, D. / Rodriguez-Viciana, P. / Stephen, A.G. / Simanshu, D.K. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 7tvf.cif.gz | 844.6 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb7tvf.ent.gz | 688.7 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 7tvf.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/tv/7tvf ftp://data.pdbj.org/pub/pdb/validation_reports/tv/7tvf | HTTPS FTP |
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-関連構造データ
関連構造データ | 7tvgC 1x1sS 6dnoS S: 精密化の開始モデル C: 同じ文献を引用 (文献) |
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類似構造データ | 類似検索 - 機能・相同性F&H 検索 |
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非結晶学的対称性 (NCS) | NCSドメイン:
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