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Yorodumi- PDB-7tvf: Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a reso... -
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-Basic information
Entry | Database: PDB / ID: 7tvf | ||||||
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Title | Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom | ||||||
Components |
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Keywords | SIGNALING PROTEIN / Oncoprotein Phosphatase Scaffold protein Adaptor RAS Leucine rich repeat | ||||||
Function / homology | Function and homology information cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / nerve growth factor signaling pathway / protein phosphatase 1 binding / protein phosphatase regulator activity ...cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / nerve growth factor signaling pathway / protein phosphatase 1 binding / protein phosphatase regulator activity / cadherin binding involved in cell-cell adhesion / GTP-dependent protein binding / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of Ras protein signal transduction / regulation of canonical Wnt signaling pathway / regulation of translational initiation / myosin phosphatase activity / protein serine/threonine phosphatase activity / branching morphogenesis of an epithelial tube / glycogen metabolic process / protein-serine/threonine phosphatase / entrainment of circadian clock by photoperiod / Triglyceride catabolism / phosphatase activity / phosphoprotein phosphatase activity / DARPP-32 events / negative regulation of neuron differentiation / fibroblast growth factor receptor signaling pathway / ribonucleoprotein complex binding / dephosphorylation / positive regulation of neuron differentiation / cellular response to leukemia inhibitory factor / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / small monomeric GTPase / G protein activity / response to lead ion / adherens junction / lung development / RAF activation / circadian regulation of gene expression / regulation of circadian rhythm / positive regulation of neuron projection development / GDP binding / Circadian Clock / presynapse / perikaryon / actin cytoskeleton organization / protein phosphatase binding / Ras protein signal transduction / dendritic spine / cell cycle / cell division / GTPase activity / glutamatergic synapse / GTP binding / nucleolus / signal transduction / extracellular exosome / nucleoplasm / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.17 Å | ||||||
Authors | Bonsor, D.A. / Simanshu, D.K. | ||||||
Funding support | United States, 1items
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Citation | Journal: Nat.Struct.Mol.Biol. / Year: 2022 Title: Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Authors: Bonsor, D.A. / Alexander, P. / Snead, K. / Hartig, N. / Drew, M. / Messing, S. / Finci, L.I. / Nissley, D.V. / McCormick, F. / Esposito, D. / Rodriguez-Viciana, P. / Stephen, A.G. / Simanshu, D.K. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7tvf.cif.gz | 844.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7tvf.ent.gz | 688.7 KB | Display | PDB format |
PDBx/mmJSON format | 7tvf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tv/7tvf ftp://data.pdbj.org/pub/pdb/validation_reports/tv/7tvf | HTTPS FTP |
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-Related structure data
Related structure data | 7tvgC 1x1sS 6dnoS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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