- PDB-7rec: Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464Hi... -
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Basic information
Entry
Database: PDB / ID: 7rec
Title
Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC
Components
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Keywords
SIGNALING PROTEIN / CaMKII hub / oligomer
Function / homology
Function and homology information
peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity ...peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity / Assembly and cell surface presentation of NMDA receptors / regulation of mitochondrial membrane permeability involved in apoptotic process / calmodulin-dependent protein kinase activity / CaMK IV-mediated phosphorylation of CREB / positive regulation of cardiac muscle cell apoptotic process / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / regulation of neuronal synaptic plasticity / Phase 0 - rapid depolarisation / Ion transport by P-type ATPases / Long-term potentiation / Regulation of MECP2 expression and activity / HSF1-dependent transactivation / cellular response to interferon-beta / glutamate receptor binding / Ion homeostasis / Ras activation upon Ca2+ influx through NMDA receptor / response to ischemia / angiotensin-activated signaling pathway / RAF activation / positive regulation of receptor signaling pathway via JAK-STAT / G1/S transition of mitotic cell cycle / cellular response to type II interferon / Signaling by RAF1 mutants / calcium ion transport / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / endocytic vesicle membrane / Interferon gamma signaling / Signaling by BRAF and RAF1 fusions / Ca2+ pathway / kinase activity / positive regulation of NF-kappaB transcription factor activity / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / dendritic spine / protein autophosphorylation / postsynaptic density / calmodulin binding / neuron projection / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein homodimerization activity / mitochondrion / nucleoplasm / ATP binding / identical protein binding / metal ion binding / nucleus / cytosol / cytoplasm Similarity search - Function
Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
5-hydroxydiclofenac / Calcium/calmodulin-dependent protein kinase type II subunit alpha Similarity search - Component
G: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha F: Calcium/calmodulin-dependent protein kinase type II subunit alpha hetero molecules
G: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha F: Calcium/calmodulin-dependent protein kinase type II subunit alpha hetero molecules
G: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha F: Calcium/calmodulin-dependent protein kinase type II subunit alpha hetero molecules
Mass: 18.015 Da / Num. of mol.: 87 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interest
Y
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.27 Å3/Da / Density % sol: 45.78 %
Crystal grow
Temperature: 298 K / Method: vapor diffusion, sitting drop / pH: 8.1 Details: 100 nL protein + compound in 25 mM Tris, 150 mM potassium chloride, 2 mM DTT, 1 mM TCEP, 10% v/v glycerol, pH 8.0, 10% DMSO + 100 nL well solution (200 mM potassium acetate, 20% w/v PEG3350, ...Details: 100 nL protein + compound in 25 mM Tris, 150 mM potassium chloride, 2 mM DTT, 1 mM TCEP, 10% v/v glycerol, pH 8.0, 10% DMSO + 100 nL well solution (200 mM potassium acetate, 20% w/v PEG3350, pH 8.1), equilibrated against 45 uL well solution
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Data collection
Diffraction
Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source
Source: SYNCHROTRON / Site: ALS / Beamline: 8.3.1 / Wavelength: 1.11583 Å