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Yorodumi- PDB-7mcp: Crystal structure of Staphylococcus aureus Cystathionine gamma-ly... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7mcp | ||||||||||||
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Title | Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme dimer | ||||||||||||
Components | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase | ||||||||||||
Keywords | LYASE / Amino-acid biosynthesis / Cysteine biosynthesis / Hydrogen sulfide production / PLP dependent enzyme | ||||||||||||
Function / homology | Function and homology information cystathionine gamma-synthase / cystathionine gamma-synthase activity (acts on O-phosphohomoserine) / cystathionine gamma-synthase activity / cystathionine beta-lyase / cystathionine gamma-lyase / L-cystine L-cysteine-lyase (deaminating) / : / cystathionine gamma-lyase activity / L-cysteine desulfhydrase activity / transsulfuration ...cystathionine gamma-synthase / cystathionine gamma-synthase activity (acts on O-phosphohomoserine) / cystathionine gamma-synthase activity / cystathionine beta-lyase / cystathionine gamma-lyase / L-cystine L-cysteine-lyase (deaminating) / : / cystathionine gamma-lyase activity / L-cysteine desulfhydrase activity / transsulfuration / pyridoxal phosphate binding / identical protein binding / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Staphylococcus aureus (bacteria) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å | ||||||||||||
Authors | Nuthanakanti, A. / Serganov, A. / Kaushik, A. | ||||||||||||
Funding support | United States, 3items
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Citation | Journal: Science / Year: 2021 Title: Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Authors: Shatalin, K. / Nuthanakanti, A. / Kaushik, A. / Shishov, D. / Peselis, A. / Shamovsky, I. / Pani, B. / Lechpammer, M. / Vasilyev, N. / Shatalina, E. / Rebatchouk, D. / Mironov, A. / ...Authors: Shatalin, K. / Nuthanakanti, A. / Kaushik, A. / Shishov, D. / Peselis, A. / Shamovsky, I. / Pani, B. / Lechpammer, M. / Vasilyev, N. / Shatalina, E. / Rebatchouk, D. / Mironov, A. / Fedichev, P. / Serganov, A. / Nudler, E. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7mcp.cif.gz | 208.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7mcp.ent.gz | 132 KB | Display | PDB format |
PDBx/mmJSON format | 7mcp.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/mc/7mcp ftp://data.pdbj.org/pub/pdb/validation_reports/mc/7mcp | HTTPS FTP |
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-Related structure data
Related structure data | 7mcbC 7mclC 7mcnC 7mcqC 7mctC 7mcuC 7mcyC 7md0C 7md1C 7md6C 7md8C 7md9C 7mdaC 7mdbC 4ixzS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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