Entry Database : PDB / ID : 7cqp Structure visualization Downloads & linksTitle Complex of TRPC4 and Calmodulin_Nlobe ComponentsCalmodulin-1 Peptide from Short transient receptor potential channel 4 DetailsKeywords SIGNALING PROTEIN / Calmodulin / TRP channelFunction / homology Function and homology informationFunction Domain/homology Component
regulation of action potential firing rate / positive regulation of store-operated calcium entry / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor ... regulation of action potential firing rate / positive regulation of store-operated calcium entry / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calcineurin activates NFAT / eNOS activation / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / Protein methylation / RAF activation / VEGFR2 mediated vascular permeability / RAS processing / Smooth Muscle Contraction / gamma-aminobutyric acid secretion / Ca2+ pathway / FCERI mediated Ca+2 mobilization / RAF/MAP kinase cascade / RHO GTPases activate IQGAPs / Extra-nuclear estrogen signaling / store-operated calcium channel activity / PKA activation / Platelet degranulation / cation channel complex / TRP channels / Stimuli-sensing channels / Ion homeostasis / type 3 metabotropic glutamate receptor binding / inositol 1,4,5 trisphosphate binding / calcium ion import / organelle localization by membrane tethering / mitochondrion-endoplasmic reticulum membrane tethering / regulation of cardiac muscle cell action potential / autophagosome membrane docking / cortical cytoskeleton / nitric-oxide synthase binding / oligodendrocyte differentiation / protein phosphatase activator activity / regulation of calcium ion transport / adenylate cyclase binding / catalytic complex / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity / regulation of cardiac muscle contraction / calcium channel inhibitor activity / cellular response to interferon-beta / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of protein dephosphorylation / voltage-gated potassium channel complex / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / sperm midpiece / calcium channel complex / regulation of cytosolic calcium ion concentration / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / caveola / calcium ion transmembrane transport / positive regulation of receptor signaling pathway via JAK-STAT / calcium channel activity / spindle microtubule / beta-catenin binding / cellular response to type II interferon / spindle pole / calcium ion transport / calcium-dependent protein binding / G2/M transition of mitotic cell cycle / cell-cell junction / myelin sheath / growth cone / basolateral plasma membrane / transmembrane transporter binding / cadherin binding / membrane raft / protein domain specific binding / centrosome / calcium ion binding / protein kinase binding / cell surface / protein-containing complex / nucleoplasm / plasma membrane / cytosol / cytoplasm Similarity search - Function Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor ion channel II / Transient receptor potential channel, canonical / Ankyrin repeat / EF-hand domain pair / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. ... Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor ion channel II / Transient receptor potential channel, canonical / Ankyrin repeat / EF-hand domain pair / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Ion transport domain / Ion transport protein / EF-hand domain pair Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.9 Å DetailsAuthors Shen, Z.S. Funding support China, 2items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 31670765 China National Natural Science Foundation of China (NSFC) 31870746 China
CitationJournal : Structure / Year : 2021Title : Calmodulin binds to Drosophila TRP with an unexpected mode.Authors : Chen, W. / Shen, Z. / Asteriti, S. / Chen, Z. / Ye, F. / Sun, Z. / Wan, J. / Montell, C. / Hardie, R.C. / Liu, W. / Zhang, M. History Deposition Aug 11, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 23, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Nov 29, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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