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Yorodumi- PDB-6uq8: Crystal structure of R421A variant of cytosolic fumarate hydratas... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6uq8 | ||||||||||||
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Title | Crystal structure of R421A variant of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate and malonate | ||||||||||||
Components | Fumarate hydratase 2Fumarase | ||||||||||||
Keywords | LYASE / fumarate hydratase / fumarase / Leishmania major / variant R421A / substrate / S-malate / inhibitor / malonate | ||||||||||||
Function / homology | Function and homology information fumarate hydratase activity / fumarate hydratase / fumarate metabolic process / malate metabolic process / glycosome / ciliary plasm / generation of precursor metabolites and energy / 4 iron, 4 sulfur cluster binding / protein homodimerization activity / metal ion binding ...fumarate hydratase activity / fumarate hydratase / fumarate metabolic process / malate metabolic process / glycosome / ciliary plasm / generation of precursor metabolites and energy / 4 iron, 4 sulfur cluster binding / protein homodimerization activity / metal ion binding / cytosol / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Leishmania major strain Friedlin (eukaryote) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.339 Å | ||||||||||||
Authors | Feliciano, P.R. / Drennan, C.L. | ||||||||||||
Funding support | Brazil, United States, 3items
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Citation | Journal: Biochemistry / Year: 2019 Title: Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major. Authors: Feliciano, P.R. / Drennan, C.L. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6uq8.cif.gz | 659.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6uq8.ent.gz | 551.2 KB | Display | PDB format |
PDBx/mmJSON format | 6uq8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/uq/6uq8 ftp://data.pdbj.org/pub/pdb/validation_reports/uq/6uq8 | HTTPS FTP |
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-Related structure data
Related structure data | 6unzC 6uo0C 6uoiC 6uojC 6up9C 6upmC 6upoC 6uq9C 6uqbC 6uqlC 6uqmC 6uqnC 5l2rS C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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