登録情報 | データベース: PDB / ID: 6uc6 |
---|
タイトル | Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11 |
---|
要素 | - Botulinum neurotoxin type B
- JLI-H11
|
---|
キーワード | HYDROLASE/ANTITOXIN / Botulinum neurotoxin (BoNT) / VHH / receptor-binding domain / TOXIN (毒素) / ANTITOXIN (抗毒素) / HYDROLASE-ANTITOXIN complex |
---|
機能・相同性 | 機能・相同性情報
Toxicity of botulinum toxin type B (botB) / ボツリヌストキシン / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol / protein transmembrane transporter activity / metalloendopeptidase activity / toxin activity / lipid binding / host cell plasma membrane ...Toxicity of botulinum toxin type B (botB) / ボツリヌストキシン / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol / protein transmembrane transporter activity / metalloendopeptidase activity / toxin activity / lipid binding / host cell plasma membrane / タンパク質分解 / zinc ion binding / extracellular region / 生体膜類似検索 - 分子機能 Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily ...Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Jelly Rolls - #200 / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / サンドイッチ / Mainly Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Clostridium botulinum (ボツリヌス菌) Vicugna pacos (アルパカ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.32005878384 Å |
---|
データ登録者 | Lam, K. / Jin, R. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | | 米国 |
|
---|
引用 | ジャーナル: Cell Rep / 年: 2020 タイトル: Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins 著者: Lam, K. / Tremblay, J.M. / Vazquez-Cintron, E. / Perry, K. / Ondeck, C. / Webb, R. / McNutt, P.M. / Shoemaker, C.B. / Jin, R. |
---|
履歴 | 登録 | 2019年9月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2020年3月4日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|