登録情報 | データベース: PDB / ID: 6tyy |
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タイトル | Hedgehog autoprocessing mutant D46H |
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要素 | Protein hedgehog |
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キーワード | SIGNALING PROTEIN / Hedgehog autoprocessing doamin |
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機能・相同性 | 機能・相同性情報
progression of morphogenetic furrow involved in compound eye morphogenesis / negative regulation of homotypic cell-cell adhesion / terminal cell fate specification, open tracheal system / cytoneme assembly / germ cell attraction / wing disc proximal/distal pattern formation / labial disc development / regulation of cell proliferation involved in compound eye morphogenesis / Bolwig's organ morphogenesis / Release of Hh-Np from the secreting cell ...progression of morphogenetic furrow involved in compound eye morphogenesis / negative regulation of homotypic cell-cell adhesion / terminal cell fate specification, open tracheal system / cytoneme assembly / germ cell attraction / wing disc proximal/distal pattern formation / labial disc development / regulation of cell proliferation involved in compound eye morphogenesis / Bolwig's organ morphogenesis / Release of Hh-Np from the secreting cell / Ligand-receptor interactions / leg disc morphogenesis / Formation and transport of the N-HH ligand / regulation of epithelial cell migration, open tracheal system / morphogenesis of larval imaginal disc epithelium / cell-cell signaling involved in cell fate commitment / Assembly of the 'signalling complexes' / gonadal mesoderm development / compound eye photoreceptor cell differentiation / wing disc pattern formation / Hedgehog ligand biogenesis / : / analia development / anterior head segmentation / posterior head segmentation / imaginal disc growth / anterior/posterior lineage restriction, imaginal disc / epithelial cell migration, open tracheal system / trunk segmentation / heart formation / genital disc development / genital disc anterior/posterior pattern formation / compound eye morphogenesis / spiracle morphogenesis, open tracheal system / wing disc anterior/posterior pattern formation / morphogen activity / mucosal immune response / hindgut morphogenesis / segment polarity determination / ventral midline development / foregut morphogenesis / cholesterol-protein transferase activity / imaginal disc-derived wing morphogenesis / compartment pattern specification / glial cell migration / developmental pigmentation / patched binding / germ cell migration / self proteolysis / embryonic pattern specification / positive regulation of protein localization to cell surface / intein-mediated protein splicing / cell fate specification / smoothened signaling pathway / positive regulation of neuroblast proliferation / protein autoprocessing / endocytic vesicle / epidermis development / regulation of mitotic cell cycle / negative regulation of proteolysis / heart development / peptidase activity / cytoplasmic vesicle / 遺伝子発現の調節 / 加水分解酵素; エステル加水分解酵素 / エンドソーム / calcium ion binding / extracellular space / extracellular region / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Endonuclease - Pi-scei; Chain A, domain 1 / Hedgehog/Intein (Hint) domain / Hedgehog, N-terminal signalling domain / ヘッジホッグシグナル伝達経路 / Hedgehog protein, Hint domain / Hint module / Hedgehog amino-terminal signalling domain / Hedgehog signalling/DD-peptidase zinc-binding domain superfamily / Hint domain C-terminal / Hint (Hedgehog/Intein) domain C-terminal region ...Endonuclease - Pi-scei; Chain A, domain 1 / Hedgehog/Intein (Hint) domain / Hedgehog, N-terminal signalling domain / ヘッジホッグシグナル伝達経路 / Hedgehog protein, Hint domain / Hint module / Hedgehog amino-terminal signalling domain / Hedgehog signalling/DD-peptidase zinc-binding domain superfamily / Hint domain C-terminal / Hint (Hedgehog/Intein) domain C-terminal region / Intein N-terminal splicing region / Intein N-terminal splicing motif profile. / Hint domain N-terminal / Hint (Hedgehog/Intein) domain N-terminal region / Hint domain superfamily / Beta Complex / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Drosophila melanogaster (キイロショウジョウバエ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.36 Å |
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データ登録者 | Li, H. / Li, Z. / Wang, C. / Callahan, B.P. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI140726 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI141178 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA206592 | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2019 タイトル: General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. 著者: Zhao, J. / Ciulla, D.A. / Xie, J. / Wagner, A.G. / Castillo, D.A. / Zwarycz, A.S. / Lin, Z. / Beadle, S. / Giner, J.L. / Li, Z. / Li, H. / Banavali, N. / Callahan, B.P. / Wang, C. |
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履歴 | 登録 | 2019年8月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年11月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年12月4日 | Group: Author supporting evidence / Database references カテゴリ: citation / citation_author / pdbx_audit_support Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID / _pdbx_audit_support.funding_organization |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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