Entry Database : PDB / ID : 6qhd Structure visualization Downloads & linksTitle Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA ComponentsDNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3')DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3')Signal transducer and activator of transcription 3 DetailsKeywords TRANSCRIPTION / Lysine Acetylation / DNA Binding / Post Translational Modification / non canonical Amino AcidFunction / homology Function and homology informationFunction Domain/homology Component
RNA sequestering activity / positive regulation of metalloendopeptidase activity / PTK6 Activates STAT3 / eye photoreceptor cell differentiation / retinal rod cell differentiation / radial glial cell differentiation / cell surface receptor signaling pathway via STAT / negative regulation of primary miRNA processing / leptin-mediated signaling pathway / negative regulation of neuron migration ... RNA sequestering activity / positive regulation of metalloendopeptidase activity / PTK6 Activates STAT3 / eye photoreceptor cell differentiation / retinal rod cell differentiation / radial glial cell differentiation / cell surface receptor signaling pathway via STAT / negative regulation of primary miRNA processing / leptin-mediated signaling pathway / negative regulation of neuron migration / T-helper 17 type immune response / Signalling to STAT3 / negative regulation of inflammatory response to wounding / primary miRNA binding / POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation / response to leptin / regulation of feeding behavior / sexual reproduction / interleukin-11-mediated signaling pathway / T-helper 17 cell lineage commitment / cellular response to interleukin-17 / Transcriptional regulation of pluripotent stem cells / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / MET activates STAT3 / interleukin-2-mediated signaling pathway / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / intracellular receptor signaling pathway / negative regulation of stem cell differentiation / interleukin-15-mediated signaling pathway / cellular response to leptin stimulus / STAT3 nuclear events downstream of ALK signaling / astrocyte differentiation / Interleukin-23 signaling / positive regulation of cytokine production involved in inflammatory response / Signaling by cytosolic FGFR1 fusion mutants / Interleukin-37 signaling / Interleukin-15 signaling / Signaling by Leptin / Interleukin-35 Signalling / Interleukin-27 signaling / negative regulation of glycolytic process / positive regulation of vascular endothelial cell proliferation / growth hormone receptor signaling pathway / temperature homeostasis / eating behavior / Signaling by ALK / Interleukin-20 family signaling / interleukin-6-mediated signaling pathway / Interleukin-6 signaling / positive regulation of Notch signaling pathway / Association of TriC/CCT with target proteins during biosynthesis / Interleukin-10 signaling / somatic stem cell population maintenance / cell surface receptor signaling pathway via JAK-STAT / positive regulation of interleukin-10 production / regulation of multicellular organism growth / positive regulation of vascular endothelial growth factor production / Nuclear events stimulated by ALK signaling in cancer / growth hormone receptor signaling pathway via JAK-STAT / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / signaling adaptor activity / energy homeostasis / Growth hormone receptor signaling / Signaling by CSF3 (G-CSF) / cellular response to hormone stimulus / Interleukin-7 signaling / Downstream signal transduction / negative regulation of autophagy / transforming growth factor beta receptor signaling pathway / positive regulation of erythrocyte differentiation / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of interleukin-1 beta production / positive regulation of interleukin-8 production / mRNA transcription by RNA polymerase II / Signaling by ALK fusions and activated point mutants / PKR-mediated signaling / Inactivation of CSF3 (G-CSF) signaling / Signaling by SCF-KIT / Cytoprotection by HMOX1 / chromatin DNA binding / response to peptide hormone / defense response / cytokine-mediated signaling pathway / negative regulation of inflammatory response / positive regulation of miRNA transcription / Transcriptional regulation of granulopoiesis / protein import into nucleus / RNA polymerase II transcription regulator complex / positive regulation of angiogenesis / positive regulation of interleukin-6 production / nuclear receptor activity / Signaling by CSF1 (M-CSF) in myeloid cells / positive regulation of tumor necrosis factor production / response to estradiol / glucose homeostasis / nervous system development Similarity search - Function STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding domain / STAT3, SH2 domain / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain ... STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding domain / STAT3, SH2 domain / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / SH2 domain / SHC Adaptor Protein / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / p53-like transcription factor, DNA-binding / EF-hand / Recoverin; domain 1 / SH2 domain / Src homology 2 (SH2) domain profile. / SH2 domain / SH2 domain superfamily / Up-down Bundle / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human) Murine adenovirus 1Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.85 Å DetailsAuthors Arbely, E. / Belo, Y. / Shahar, A. / Zarivach, R. Funding support Israel, 1items Details Hide detailsOrganization Grant number Country Israel Science Foundation 807/15 Israel
CitationJournal : Biochim Biophys Acta Gen Subj / Year : 2019Title : Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.Authors : Belo, Y. / Mielko, Z. / Nudelman, H. / Afek, A. / Ben-David, O. / Shahar, A. / Zarivach, R. / Gordan, R. / Arbely, E. History Deposition Jan 16, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 19, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jun 26, 2019 Group : Data collection / Database references / Category : citation / pdbx_seq_map_depositor_infoItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _pdbx_seq_map_depositor_info.one_letter_code_mod Revision 1.2 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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