登録情報 | データベース: PDB / ID: 6qb6 |
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タイトル | Mcl1 in complex with a Fab |
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要素 | - Fab Heavy ChainFragment antigen-binding
- Fab Light ChainFragment antigen-binding
- Induced myeloid leukemia cell differentiation protein Mcl-1
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キーワード | APOPTOSIS (アポトーシス) / Mcl1 / Fab / AZD5991 |
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機能・相同性 | 機能・相同性情報
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / 拘束 (生物学) / mitochondrial fusion / channel activity / Bcl-2 family protein complex / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ...positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / 拘束 (生物学) / mitochondrial fusion / channel activity / Bcl-2 family protein complex / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / Signaling by ALK fusions and activated point mutants / intrinsic apoptotic signaling pathway in response to DNA damage / regulation of apoptotic process / Interleukin-4 and Interleukin-13 signaling / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / protein homodimerization activity / ミトコンドリア / 核質 / 生体膜 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions ...Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2ファミリー / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Bcl-2ファミリー / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / 抗体 / Immunoglobulin-like / サンドイッチ / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 Induced myeloid leukemia cell differentiation protein Mcl-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.24 Å |
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データ登録者 | Hargreaves, D. |
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引用 | ジャーナル: Acta Crystallogr D Struct Biol / 年: 2019 タイトル: Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1. 著者: Luptak, J. / Bista, M. / Fisher, D. / Flavell, L. / Gao, N. / Wickson, K. / Kazmirski, S.L. / Howard, T. / Rawlins, P.B. / Hargreaves, D. |
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履歴 | 登録 | 2018年12月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年11月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年11月13日 | Group: Database references / カテゴリ: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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