登録情報 データベース : PDB / ID : 6q6r 構造の表示 ダウンロードとリンクタイトル Recognition of different base tetrads by RHAU: X-ray crystal structure of G4 recognition motif bound to the 3-end tetrad of a DNA G-quadruplex 要素ATP-dependent DNA/RNA helicase DHX36 Parallel stranded DNA G-quadruplex 詳細キーワード DNA BINDING PROTEIN (DNA結合タンパク質) / G-quadruplex (グアニン四重鎖) / X-ray crystallography (X線回折) / RHAU helicase / DHX36 / G4R1 / Mle1 / DEAH-box family.機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of intracellular mRNA localization / positive regulation of hematopoietic progenitor cell differentiation / positive regulation of cardioblast differentiation / positive regulation of mRNA 3'-end processing / telomerase RNA stabilization / positive regulation of telomere maintenance via telomere lengthening / pre-miRNA binding / G-quadruplex DNA unwinding / positive regulation of myeloid dendritic cell cytokine production / DEx/H-box helicases activate type I IFN and inflammatory cytokines production ... positive regulation of intracellular mRNA localization / positive regulation of hematopoietic progenitor cell differentiation / positive regulation of cardioblast differentiation / positive regulation of mRNA 3'-end processing / telomerase RNA stabilization / positive regulation of telomere maintenance via telomere lengthening / pre-miRNA binding / G-quadruplex DNA unwinding / positive regulation of myeloid dendritic cell cytokine production / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / RNA secondary structure unwinding / G-quadruplex DNA binding / positive regulation of dendritic spine morphogenesis / 3'-UTR-mediated mRNA destabilization / mRNA 3'-UTR AU-rich region binding / regulation of transcription by RNA polymerase III / positive regulation of telomere maintenance / positive regulation of cytoplasmic translation / cellular response to arsenite ion / telomerase RNA binding / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / response to exogenous dsRNA / regulation of embryonic development / positive regulation of transcription initiation by RNA polymerase II / positive regulation of interferon-alpha production / ATP-dependent activity, acting on DNA / regulation of mRNA stability / DNA helicase activity / 骨化 / mRNA 3'-UTR binding / mRNA 5'-UTR binding / histone deacetylase binding / cytoplasmic stress granule / cellular response to UV / double-stranded RNA binding / single-stranded DNA binding / cellular response to heat / G-quadruplex RNA binding / 精子形成 / perikaryon / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / ヘリカーゼ / chromosome, telomeric region / RNA helicase activity / negative regulation of translation / 細胞分化 / transcription cis-regulatory region binding / ヘリカーゼ / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / 神経繊維 / 自然免疫系 / 樹状突起 / positive regulation of gene expression / magnesium ion binding / ATP hydrolysis activity / positive regulation of transcription by RNA polymerase II / ミトコンドリア / RNA binding / extracellular exosome / 核質 / ATP binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / DEAD/DEAH box helicase ... : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase 類似検索 - ドメイン・相同性 : / デオキシリボ核酸 / DNA (> 10) / ATP-dependent DNA/RNA helicase DHX36 類似検索 - 構成要素生物種 unidentified (未定義) Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.5 Å 詳細データ登録者 Heddi, B. / Cheong, V.V. / Schmitt, E. / Mechulam, Y. / Phan, A.T. 資金援助 シンガポール, 2件 詳細 詳細を隠す組織 認可番号 国 National Research Foundation (Singapore) NRF-NRFI2017-09 シンガポール Ministry of Education (Singapore) MOE2012-T3-1-001 シンガポール
引用ジャーナル : J.Struct.Biol. / 年 : 2020タイトル : Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex.著者 : Heddi, B. / Cheong, V.V. / Schmitt, E. / Mechulam, Y. / Phan, A.T. 履歴 登録 2018年12月11日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年10月16日 Provider : repository / タイプ : Initial release改定 1.1 2019年11月27日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.page_first / _citation.page_last ... _citation.page_first / _citation.page_last / _citation.title / _citation_author.name 改定 1.2 2020年1月22日 Group : Database references / カテゴリ : citation / Item : _citation.journal_volume / _citation.year改定 1.3 2022年7月13日 Group : Database references / Derived calculations / Structure summaryカテゴリ : audit_author / database_2 ... audit_author / database_2 / pdbx_struct_conn_angle / struct_conn Item : _audit_author.name / _database_2.pdbx_DOI ... _audit_author.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_alt_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_alt_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id 改定 1.4 2024年1月24日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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