登録情報 | データベース: PDB / ID: 6nuf |
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タイトル | Structure of Calcineurin in complex with NHE1 peptide |
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要素 | - Calcineurin subunit B type 1カルシニューリン
- Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
- Sodium/hydrogen exchanger 1
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キーワード | HYDROLASE/Calcium Binding Protein / Ser/thr phosphatase / complex / HYDROLASE (加水分解酵素) / HYDROLASE-Calcium Binding Protein complex |
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機能・相同性 | 機能・相同性情報
negative regulation of angiotensin-activated signaling pathway / regulation of cell proliferation involved in kidney morphogenesis / sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential / cation-transporting ATPase complex / calcium-dependent protein serine/threonine phosphatase regulator activity / positive regulation of glomerulus development / Sodium/Proton exchangers / negative regulation of calcium ion import across plasma membrane / calcium-dependent protein serine/threonine phosphatase activity / negative regulation of signaling ...negative regulation of angiotensin-activated signaling pathway / regulation of cell proliferation involved in kidney morphogenesis / sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential / cation-transporting ATPase complex / calcium-dependent protein serine/threonine phosphatase regulator activity / positive regulation of glomerulus development / Sodium/Proton exchangers / negative regulation of calcium ion import across plasma membrane / calcium-dependent protein serine/threonine phosphatase activity / negative regulation of signaling / protein serine/threonine phosphatase complex / positive regulation of saliva secretion / regulation of the force of heart contraction by cardiac conduction / positive regulation of cardiac muscle hypertrophy in response to stress / positive regulation of calcium:sodium antiporter activity / positive regulation of calcium ion import across plasma membrane / Hyaluronan uptake and degradation / calmodulin-dependent protein phosphatase activity / regulation of cardiac muscle cell membrane potential / calcineurin complex / positive regulation of connective tissue replacement / slit diaphragm / negative regulation of dendrite morphogenesis / calcineurin-mediated signaling / cellular response to electrical stimulus / potassium:proton antiporter activity / sodium:proton antiporter activity / peptidyl-serine dephosphorylation / positive regulation of action potential / lung epithelial cell differentiation / calcineurin-NFAT signaling cascade / renal filtration / skeletal muscle tissue regeneration / sodium ion export across plasma membrane / regulation of synaptic vesicle cycle / maintenance of cell polarity / transition between fast and slow fiber / regulation of pH / positive regulation of calcineurin-NFAT signaling cascade / myelination in peripheral nervous system / cardiac muscle cell differentiation / cellular response to acidic pH / intracellular sodium ion homeostasis / sodium ion import across plasma membrane / protein phosphatase 2B binding / ion binding / regulation of stress fiber assembly / cardiac muscle cell contraction / response to acidic pH / positive regulation of osteoclast differentiation / cardiac muscle hypertrophy in response to stress / regulation of postsynaptic neurotransmitter receptor internalization / positive regulation of mitochondrial membrane permeability / parallel fiber to Purkinje cell synapse / dendrite morphogenesis / regulation of cardiac muscle contraction by calcium ion signaling / cellular response to cold / cellular response to antibiotic / regulation of focal adhesion assembly / cyclosporin A binding / branching involved in blood vessel morphogenesis / myosin phosphatase activity / CLEC7A (Dectin-1) induces NFAT activation / extrinsic component of plasma membrane / postsynaptic modulation of chemical synaptic transmission / protein serine/threonine phosphatase activity / protein-serine/threonine phosphatase / positive regulation of cardiac muscle hypertrophy / positive regulation of activated T cell proliferation / positive regulation of endocytosis / positive regulation of the force of heart contraction / Calcineurin activates NFAT / cellular response to organic cyclic compound / positive regulation of cell adhesion / 介在板 / DARPP-32 events / negative regulation of insulin secretion / Activation of BAD and translocation to mitochondria / epidermis development / 上皮間葉転換 / phosphatase binding / positive regulation of osteoblast differentiation / multicellular organismal response to stress / skeletal muscle fiber development / monoatomic ion transport / 脱リン酸化 / potassium ion transmembrane transport / keratinocyte differentiation / 横行小管 / cellular response to epinephrine stimulus / proton transmembrane transport / phosphatidylinositol-4,5-bisphosphate binding / response to amphetamine / response to muscle stretch / T細胞 / excitatory postsynaptic potential / hippocampal mossy fiber to CA3 synapse / FCERI mediated Ca+2 mobilization / protein dephosphorylation / 細胞分化類似検索 - 分子機能 Sodium/hydrogen exchanger 1-like / Calcineurin B protein / Sodium/hydrogen exchanger, regulatory region / Regulatory region of Na+/H+ exchanger NHE binds to calmodulin / Na+/H+ exchanger / PP2B, metallophosphatase domain / PP2B / Cation/H+ exchanger, CPA1 family / Cation/H+ exchanger / Sodium/hydrogen exchanger family ...Sodium/hydrogen exchanger 1-like / Calcineurin B protein / Sodium/hydrogen exchanger, regulatory region / Regulatory region of Na+/H+ exchanger NHE binds to calmodulin / Na+/H+ exchanger / PP2B, metallophosphatase domain / PP2B / Cation/H+ exchanger, CPA1 family / Cation/H+ exchanger / Sodium/hydrogen exchanger family / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / EFハンド / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / 4-Layer Sandwich / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 : / DI(HYDROXYETHYL)ETHER / TRIETHYLENE GLYCOL / リン酸塩 / Sodium/hydrogen exchanger 1 / Calcineurin subunit B type 1 / Protein phosphatase 3 catalytic subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Wang, X. / Page, R. / Peti, W. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R01NS091336 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM098482 | 米国 |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. 著者: Hendus-Altenburger, R. / Wang, X. / Sjogaard-Frich, L.M. / Pedraz-Cuesta, E. / Sheftic, S.R. / Bendsoe, A.H. / Page, R. / Kragelund, B.B. / Pedersen, S.F. / Peti, W. |
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履歴 | 登録 | 2019年1月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年7月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月21日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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