登録情報 | データベース: PDB / ID: 6m64 |
---|
タイトル | Crystal structure of SMAD2 in complex with CBP |
---|
要素 | - CBP
- Mothers against decapentaplegic homolog 2
|
---|
キーワード | SIGNALING PROTEIN / TGF-beta (TGF-β) / Complex / Transcription factor (転写因子) |
---|
機能・相同性 | 機能・相同性情報
zygotic specification of dorsal/ventral axis / regulation of binding / homomeric SMAD protein complex / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / SMAD protein complex / endoderm formation ...zygotic specification of dorsal/ventral axis / regulation of binding / homomeric SMAD protein complex / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / SMAD protein complex / endoderm formation / co-SMAD binding / heteromeric SMAD protein complex / odontoblast differentiation / determination of left/right asymmetry in lateral mesoderm / secondary palate development / pericardium development / FOXO-mediated transcription of cell cycle genes / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / Transcriptional regulation of pluripotent stem cells / regulation of transforming growth factor beta receptor signaling pathway / embryonic foregut morphogenesis / transforming growth factor beta receptor binding / primary miRNA processing / Germ layer formation at gastrulation / pulmonary valve morphogenesis / signal transduction involved in regulation of gene expression / type I transforming growth factor beta receptor binding / Formation of definitive endoderm / activin receptor signaling pathway / Signaling by Activin / NFE2L2 regulating ER-stress associated genes / peptide N-acetyltransferase activity / Formation of axial mesoderm / positive regulation of BMP signaling pathway / SMAD protein signal transduction / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / Signaling by NODAL / regulation of smoothened signaling pathway / embryonic cranial skeleton morphogenesis / response to cholesterol / histone H3K18 acetyltransferase activity / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / NFE2L2 regulates pentose phosphate pathway genes / NFE2L2 regulating MDR associated enzymes / MRF binding / I-SMAD binding / aortic valve morphogenesis / 膵臓 / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / insulin secretion / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / RUNX3 regulates NOTCH signaling / NOTCH4 Intracellular Domain Regulates Transcription / Regulation of FOXO transcriptional activity by acetylation / Regulation of gene expression by Hypoxia-inducible Factor / Nuclear events mediated by NFE2L2 / ureteric bud development / Regulation of NFE2L2 gene expression / negative regulation of transcription by RNA polymerase I / NOTCH3 Intracellular Domain Regulates Transcription / anterior/posterior pattern specification / NFE2L2 regulating anti-oxidant/detoxification enzymes / endocardial cushion morphogenesis / TRAF6 mediated IRF7 activation / peptide-lysine-N-acetyltransferase activity / FOXO-mediated transcription of cell death genes / NFE2L2 regulating tumorigenic genes / organ growth / adrenal gland development / embryonic digit morphogenesis / homeostatic process / Notch-HLH transcription pathway / protein acetylation / Formation of paraxial mesoderm / positive regulation of transforming growth factor beta receptor signaling pathway / TGF-beta receptor signaling activates SMADs / non-canonical NF-kappaB signal transduction / SMAD binding / Zygotic genome activation (ZGA) / stimulatory C-type lectin receptor signaling pathway / acetyltransferase activity / R-SMAD binding / cellular response to nutrient levels / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / mesoderm formation / histone acetyltransferase complex / gastrulation / anatomical structure morphogenesis / positive regulation of epithelial to mesenchymal transition / phosphatase binding / Attenuation phase / 細胞分化 / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / cis-regulatory region sequence-specific DNA binding / regulation of cellular response to heat / histone acetyltransferase activity類似検索 - 分子機能 MAD homology, MH1 / Smad / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain ...MAD homology, MH1 / Smad / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Coactivator CBP, KIX domain superfamily / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / SMAD/FHA domain superfamily / Nuclear receptor coactivator, interlocking / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 2 / CREB-binding protein類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.45 Å |
---|
データ登録者 | Miyazono, K. / Ito, T. / Wada, H. / Tanokura, M. |
---|
資金援助 | 日本, 3件 組織 | 認可番号 | 国 |
---|
Japan Society for the Promotion of Science (JSPS) | 15K14708 | 日本 | Japan Society for the Promotion of Science (JSPS) | 17K19581 | 日本 | Japan Society for the Promotion of Science (JSPS) | 23228003 | 日本 |
|
---|
引用 | ジャーナル: Sci.Signal. / 年: 2020 タイトル: Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-beta signaling. 著者: Miyazono, K.I. / Ito, T. / Fukatsu, Y. / Wada, H. / Kurisaki, A. / Tanokura, M. |
---|
履歴 | 登録 | 2020年3月13日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2020年11月25日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2020年12月30日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
---|
改定 1.2 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|