+Open data
-Basic information
Entry | Database: PDB / ID: 6kj8 | |||||||||
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Title | E. coli ATCase holoenzyme mutant - G166P (catalytic chain) | |||||||||
Components |
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Keywords | TRANSFERASE / aspartate transcarbamoylase holoenzyme / de novo pyrimidine biosynthesis | |||||||||
Function / homology | Function and homology information aspartate carbamoyltransferase complex / pyrimidine nucleotide biosynthetic process / aspartate carbamoyltransferase / aspartate carbamoyltransferase activity / amino acid binding / glutamine metabolic process / protein homotrimerization / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / zinc ion binding ...aspartate carbamoyltransferase complex / pyrimidine nucleotide biosynthetic process / aspartate carbamoyltransferase / aspartate carbamoyltransferase activity / amino acid binding / glutamine metabolic process / protein homotrimerization / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / zinc ion binding / identical protein binding / cytosol / cytoplasm Similarity search - Function | |||||||||
Biological species | Escherichia coli K-12 (bacteria) | |||||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 3.011 Å | |||||||||
Authors | Lei, Z. / Zheng, J. / Jia, Z.C. | |||||||||
Funding support | China, Canada, 2items
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Citation | Journal: Febs J. / Year: 2020 Title: New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. Authors: Lei, Z. / Wang, B. / Lu, Z. / Wang, N. / Tan, H. / Zheng, J. / Jia, Z. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6kj8.cif.gz | 508 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6kj8.ent.gz | 419.5 KB | Display | PDB format |
PDBx/mmJSON format | 6kj8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/kj/6kj8 ftp://data.pdbj.org/pub/pdb/validation_reports/kj/6kj8 | HTTPS FTP |
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-Related structure data
Related structure data | 6kj7C 6kj9C 6kjaC 1za1S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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