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- PDB-6hsc: Structure of Human Serum Albumin in complex with Aristolochic Aci... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6hsc | ||||||
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Title | Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution | ||||||
![]() | Serum albumin![]() | ||||||
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Function / homology | ![]() cellular response to calcium ion starvation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Pomyalov, S. / Sidorenko, V.S. / Grollman, A.P. / Shoham, G. | ||||||
![]() | ![]() Title: Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution Authors: Pomyalov, S. / Sidorenko, V.S. / Grollman, A.P. / Shoham, G. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 280.5 KB | Display | ![]() |
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PDB format | ![]() | 205.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 5ifoS S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 69469.695 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() Gene: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341 Production host: ![]() ![]() #2: Chemical | ChemComp-MYR / ![]() #3: Chemical | ChemComp-EDO / ![]() #4: Chemical | ChemComp-GOQ / | ![]() #5: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.24 Å3/Da / Density % sol: 45.06 % |
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Crystal grow![]() | Temperature: 298 K / Method: vapor diffusion, hanging drop Details: 34% PEG 3350, 25mM sodium Phosphate pH 7, Aristolochic Acid I. PH range: 6.5-7.5 |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 315r / Detector: CCD / Date: Jun 11, 2018 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.9→47.2 Å / Num. obs: 97374 / % possible obs: 99.1 % / Redundancy: 4.2 % / Biso Wilson estimate: 26.35 Å2 / CC1/2: 0.996 / Rmerge(I) obs: 0.078 / Rpim(I) all: 0.043 / Rrim(I) all: 0.09 / Net I/σ(I): 10 |
Reflection shell | Resolution: 1.9→1.93 Å / Redundancy: 3.8 % / Rmerge(I) obs: 0.525 / Mean I/σ(I) obs: 2.4 / Num. unique obs: 4687 / CC1/2: 0.802 / Rpim(I) all: 0.423 / Rrim(I) all: 0.609 / % possible all: 98.6 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 5IFO Resolution: 1.9→47.2 Å / SU ML: 0.2924 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 30.8946 / Stereochemistry target values: CDL v1.2
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 38.02 Å2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.9→47.2 Å
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Refine LS restraints |
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LS refinement shell |
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