登録情報 | データベース: PDB / ID: 6hr2 |
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タイトル | Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB |
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要素 | - Elongin-B
- Elongin-C
- Transcription activator BRG1
- von Hippel-Lindau disease tumor suppressor
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キーワード | TRANSCRIPTION (転写 (生物学)) / bromodomain (ブロモドメイン) / BRG1 (SMARCA4) / SMARCA4 (SMARCA4) / PROTAC (タンパク質分解誘導キメラ分子) / VHL / ternary complex |
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機能・相同性 | 機能・相同性情報
positive regulation of glucose mediated signaling pathway / bBAF complex / npBAF complex / nBAF complex / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / negative regulation of androgen receptor signaling pathway / regulation of cellular response to hypoxia / GBAF complex / neural retina development / regulation of G0 to G1 transition ...positive regulation of glucose mediated signaling pathway / bBAF complex / npBAF complex / nBAF complex / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / negative regulation of androgen receptor signaling pathway / regulation of cellular response to hypoxia / GBAF complex / neural retina development / regulation of G0 to G1 transition / Tat protein binding / EGR2 and SOX10-mediated initiation of Schwann cell myelination / RHOBTB3 ATPase cycle / nucleosome disassembly / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / regulation of nucleotide-excision repair / target-directed miRNA degradation / elongin complex / RSC-type complex / VCB complex / RNA polymerase I preinitiation complex assembly / positive regulation by host of viral transcription / ATP-dependent chromatin remodeler activity / regulation of mitotic metaphase/anaphase transition / Replication of the SARS-CoV-1 genome / SWI/SNF complex / positive regulation of double-strand break repair / Cul5-RING ubiquitin ligase complex / positive regulation of T cell differentiation / Cul2-RING ubiquitin ligase complex / nuclear androgen receptor binding / positive regulation of stem cell population maintenance / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / negative regulation of transcription elongation by RNA polymerase II / regulation of G1/S transition of mitotic cell cycle / negative regulation of cell differentiation / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / ubiquitin-like ligase-substrate adaptor activity / positive regulation of Wnt signaling pathway / Tat-mediated elongation of the HIV-1 transcript / positive regulation of myoblast differentiation / Formation of HIV-1 elongation complex containing HIV-1 Tat / ATP-dependent activity, acting on DNA / Formation of HIV elongation complex in the absence of HIV Tat / Chromatin modifying enzymes / negative regulation of signal transduction / DNA polymerase binding / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / transcription initiation-coupled chromatin remodeling / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / Interleukin-7 signaling / negative regulation of autophagy / transcription corepressor binding / helicase activity / Evasion by RSV of host interferon responses / transcription coregulator binding / transcription elongation by RNA polymerase II / transcription initiation at RNA polymerase II promoter / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / Vif-mediated degradation of APOBEC3G / Formation of the beta-catenin:TCF transactivating complex / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / lysine-acetylated histone binding / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / negative regulation of cell growth / 動原体 / 核小体 / RMTs methylate histone arginines / Regulation of expression of SLITs and ROBOs / positive regulation of DNA-binding transcription factor activity / nuclear matrix / positive regulation of miRNA transcription / ubiquitin-protein transferase activity / transcription corepressor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / p53 binding / protein-macromolecule adaptor activity / nervous system development / Neddylation / positive regulation of cold-induced thermogenesis / Replication of the SARS-CoV-2 genome / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / 遺伝子発現の調節 / proteasome-mediated ubiquitin-dependent protein catabolic process / protein-containing complex assembly / DNA-binding transcription factor binding / amyloid fibril formation類似検索 - 分子機能 SWI/SNF complex subunit BRG1 / BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / Elongin C; Chain C, domain 1 / domain in helicases and associated with SANT domains / Glutamine-Leucine-Glutamine, QLQ ...SWI/SNF complex subunit BRG1 / BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / Elongin C; Chain C, domain 1 / domain in helicases and associated with SANT domains / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / Snf2, ATP coupling domain / Snf2-ATP coupling, chromatin remodelling complex / Snf2-ATP coupling, chromatin remodelling complex / HSA domain / von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Helicase/SANT-associated domain / HSA domain profile. / Elongin B / Elongin-C / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / SKP1/BTB/POZ domain superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Helicase conserved C-terminal domain / Bromodomain-like / Histone Acetyltransferase; Chain A / Ubiquitin-like (UB roll) / Bromodomain, conserved site / Bromodomain signature. / Ubiquitin family / ブロモドメイン / Ubiquitin homologues / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Ubiquitin domain profile. / helicase superfamily c-terminal domain / ユビキチン様タンパク質 / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Ubiquitin-like domain superfamily / Roll / Up-down Bundle / Immunoglobulin-like / サンドイッチ / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-FWZ / von Hippel-Lindau disease tumor suppressor / Transcription activator BRG1 / Elongin-C / Elongin-B類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.76 Å |
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データ登録者 | Roy, M. / Bader, G. / Diers, E. / Trainor, N. / Farnaby, W. / Ciulli, A. |
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引用 | ジャーナル: Nat.Chem.Biol. / 年: 2019 タイトル: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. 著者: Farnaby, W. / Koegl, M. / Roy, M.J. / Whitworth, C. / Diers, E. / Trainor, N. / Zollman, D. / Steurer, S. / Karolyi-Oezguer, J. / Riedmueller, C. / Gmaschitz, T. / Wachter, J. / Dank, C. / ...著者: Farnaby, W. / Koegl, M. / Roy, M.J. / Whitworth, C. / Diers, E. / Trainor, N. / Zollman, D. / Steurer, S. / Karolyi-Oezguer, J. / Riedmueller, C. / Gmaschitz, T. / Wachter, J. / Dank, C. / Galant, M. / Sharps, B. / Rumpel, K. / Traxler, E. / Gerstberger, T. / Schnitzer, R. / Petermann, O. / Greb, P. / Weinstabl, H. / Bader, G. / Zoephel, A. / Weiss-Puxbaum, A. / Ehrenhofer-Wolfer, K. / Wohrle, S. / Boehmelt, G. / Rinnenthal, J. / Arnhof, H. / Wiechens, N. / Wu, M.Y. / Owen-Hughes, T. / Ettmayer, P. / Pearson, M. / McConnell, D.B. / Ciulli, A. |
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履歴 | 登録 | 2018年9月26日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年6月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年6月19日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2019年7月3日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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