登録情報 | データベース: PDB / ID: 6c95 |
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タイトル | The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex bound to HYPK |
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要素 | - Huntingtin-interacting protein K
- N-alpha-acetyltransferase 10
- N-alpha-acetyltransferase 15, NatA auxiliary subunit
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キーワード | TRANSFERASE (転移酵素) / NatA / HYPK / N-terminal acetylation (アセチル化) / Huntingtin interacting protein / protein complex (タンパク質複合体) |
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機能・相同性 | 機能・相同性情報
negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / N-terminal amino-acid Nalpha-acetyltransferase NatA / peptide-glutamate-alpha-N-acetyltransferase activity / NatA complex / peptide-serine-alpha-N-acetyltransferase activity / N-terminal protein amino acid acetylation / peptide alpha-N-acetyltransferase activity / : / N-acetyltransferase activity / internal protein amino acid acetylation ...negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / N-terminal amino-acid Nalpha-acetyltransferase NatA / peptide-glutamate-alpha-N-acetyltransferase activity / NatA complex / peptide-serine-alpha-N-acetyltransferase activity / N-terminal protein amino acid acetylation / peptide alpha-N-acetyltransferase activity / : / N-acetyltransferase activity / internal protein amino acid acetylation / protein acetylation / chromosome organization / protein folding chaperone / microtubule cytoskeleton / ribosome binding / 血管新生 / transcription regulator complex / 細胞分化 / nuclear body / protein stabilization / intracellular membrane-bounded organelle / 核小体 / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / protein-containing complex / RNA binding / 核質 / 生体膜 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Huntingtin-interacting protein K, UBA-like domain / Nascent polypeptide-associated complex subunit alpha-like, UBA domain / HYPK UBA domain / N-terminal acetyltransferase A, auxiliary subunit / N-terminal acetyltransferase A, auxiliary subunit / N-acetyltransferase Ard1-like / Tetratricopeptide repeat / Acetyltransferase (GNAT) family / Gcn5-related N-acetyltransferase (GNAT) / Gcn5-related N-acetyltransferase (GNAT) domain profile. ...Huntingtin-interacting protein K, UBA-like domain / Nascent polypeptide-associated complex subunit alpha-like, UBA domain / HYPK UBA domain / N-terminal acetyltransferase A, auxiliary subunit / N-terminal acetyltransferase A, auxiliary subunit / N-acetyltransferase Ard1-like / Tetratricopeptide repeat / Acetyltransferase (GNAT) family / Gcn5-related N-acetyltransferase (GNAT) / Gcn5-related N-acetyltransferase (GNAT) domain profile. / GNAT domain / TPR repeat region circular profile. / TPR repeat profile. / Acyl-CoA N-acyltransferase / Tetratricopeptide repeats / Tetratricopeptide repeat / Aminopeptidase / Tetratricopeptide-like helical domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 フィチン酸 / N-alpha-acetyltransferase 10 / N-alpha-acetyltransferase 15, NatA auxiliary subunit / Huntingtin-interacting protein K類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.15 Å |
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データ登録者 | Gottlieb, L. / Marmorstein, R. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35 GM118090-01 | 米国 |
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引用 | ジャーナル: Structure / 年: 2018 タイトル: Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. 著者: Gottlieb, L. / Marmorstein, R. |
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履歴 | 登録 | 2018年1月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年6月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年7月18日 | Group: Data collection / Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.page_first |
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改定 1.2 | 2020年10月14日 | Group: Structure summary / カテゴリ: chem_comp / Item: _chem_comp.pdbx_synonyms |
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改定 1.3 | 2021年7月21日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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