登録情報 | データベース: PDB / ID: 6au6 |
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タイトル | Crystal structure of GDP-bound human GNAS R201C mutant |
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要素 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
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キーワード | SIGNALING PROTEIN / G protein (Gタンパク質) / GDP / active conformation |
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機能・相同性 | 機能・相同性情報
PKA activation in glucagon signalling / hair follicle placode formation / developmental growth / intracellular transport / D1 dopamine receptor binding / positive regulation of cAMP-mediated signaling / Hedgehog 'off' state / adenylate cyclase-activating adrenergic receptor signaling pathway / activation of adenylate cyclase activity / adenylate cyclase activator activity ...PKA activation in glucagon signalling / hair follicle placode formation / developmental growth / intracellular transport / D1 dopamine receptor binding / positive regulation of cAMP-mediated signaling / Hedgehog 'off' state / adenylate cyclase-activating adrenergic receptor signaling pathway / activation of adenylate cyclase activity / adenylate cyclase activator activity / trans-Golgi network membrane / G-protein beta/gamma-subunit complex binding / 骨 / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / adenylate cyclase-activating G protein-coupled receptor signaling pathway / 認識 / 血小板 / positive regulation of GTPase activity / Glucagon-type ligand receptors / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / cellular response to catecholamine stimulus / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / ADORA2B mediated anti-inflammatory cytokines production / adenylate cyclase-activating dopamine receptor signaling pathway / cellular response to prostaglandin E stimulus / GPER1 signaling / heterotrimeric G-protein complex / sensory perception of smell / positive regulation of cold-induced thermogenesis / G alpha (i) signalling events / G alpha (s) signalling events / GTPase activity / GTP binding / extracellular exosome / 生体膜 / metal ion binding / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group S / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase ...GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group S / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(s) subunit alpha isoforms short類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Hu, Q. / Shokat, K.M. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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Howard Hughes Medical Institute (HHMI) | | 米国 | Damon Runyon Cancer Research Foundation | DRG-[2229-15] | 米国 |
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引用 | ジャーナル: Cell / 年: 2018 タイトル: Disease-Causing Mutations in the G Protein G alpha s Subvert the Roles of GDP and GTP. 著者: Hu, Q. / Shokat, K.M. |
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履歴 | 登録 | 2017年8月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年5月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月30日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2019年11月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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