- PDB-5vau: Bcl-2 complex with Beclin 1 BH3 domain -
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Basic information
Entry
Database: PDB / ID: 5vau
Title
Bcl-2 complex with Beclin 1 BH3 domain
Components
Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera
Beclin-1BECN1
Keywords
APOPTOSIS / Bcl-2 / autophagy / Beclin 1
Function / homology
Function and homology information
cellular response to aluminum ion / negative regulation of cellular pH reduction / negative regulation of retinal cell programmed cell death / pigment granule organization / channel inhibitor activity / CD8-positive, alpha-beta T cell lineage commitment / BAD-BCL-2 complex / regulation of glycoprotein biosynthetic process / melanin metabolic process / positive regulation of skeletal muscle fiber development ...cellular response to aluminum ion / negative regulation of cellular pH reduction / negative regulation of retinal cell programmed cell death / pigment granule organization / channel inhibitor activity / CD8-positive, alpha-beta T cell lineage commitment / BAD-BCL-2 complex / regulation of glycoprotein biosynthetic process / melanin metabolic process / positive regulation of skeletal muscle fiber development / phosphatidylinositol 3-kinase complex, class III / positive regulation of melanocyte differentiation / cellular response to oxygen-glucose deprivation / phosphatidylinositol 3-kinase complex, class III, type II / phosphatidylinositol 3-kinase complex, class III, type I / myeloid cell apoptotic process / osteoblast proliferation / cochlear nucleus development / response to mitochondrial depolarisation / mesenchymal cell development / retinal cell programmed cell death / positive regulation of attachment of mitotic spindle microtubules to kinetochore / positive regulation of neuron maturation / cytoplasmic side of mitochondrial outer membrane / negative regulation of osteoblast proliferation / negative regulation of lysosome organization / gland morphogenesis / positive regulation of autophagosome assembly / engulfment of apoptotic cell / renal system process / negative regulation of autophagosome assembly / regulation of cell-matrix adhesion / T cell apoptotic process / stem cell development / receptor catabolic process / negative regulation of calcium ion transport into cytosol / melanocyte differentiation / The NLRP1 inflammasome / dendritic cell apoptotic process / ear development / lymphoid progenitor cell differentiation / suppression by virus of host autophagy / protein targeting to lysosome / negative regulation of myeloid cell apoptotic process / early endosome to late endosome transport / cellular response to nitrogen starvation / negative regulation of epithelial cell apoptotic process / late endosome to vacuole transport / regulation of nitrogen utilization / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / glomerulus development / B cell apoptotic process / negative regulation of T cell apoptotic process / negative regulation of dendritic cell apoptotic process / oocyte development / positive regulation of multicellular organism growth / neuron maturation / SMAD protein signal transduction / metanephros development / regulation of viral genome replication / negative regulation of motor neuron apoptotic process / focal adhesion assembly / endoplasmic reticulum calcium ion homeostasis / phagophore assembly site / negative regulation of ossification / Translation of Replicase and Assembly of the Replication Transcription Complex / negative regulation of B cell apoptotic process / response to iron(II) ion / negative regulation of programmed cell death / response to UV-B / response to iron ion / regulation of mitochondrial membrane permeability / calcium ion transport into cytosol / negative regulation of mitochondrial depolarization / channel activity / motor neuron apoptotic process / axon regeneration / epithelial cell apoptotic process / smooth muscle cell migration / phosphatidylinositol-3-phosphate biosynthetic process / intrinsic apoptotic signaling pathway in response to oxidative stress / NFE2L2 regulating tumorigenic genes / Macroautophagy / digestive tract morphogenesis / mitotic metaphase chromosome alignment / organ growth / branching involved in ureteric bud morphogenesis / cellular response to organic substance / hair follicle morphogenesis / lysosome organization / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / B cell lineage commitment / positive regulation of cardiac muscle hypertrophy / cytoplasmic pattern recognition receptor signaling pathway / positive regulation of smooth muscle cell migration / B cell proliferation / pore complex / T cell homeostasis / BH3 domain binding Similarity search - Function
Beclin-1, BH3 domain / Beclin-1 BH3 domain, Bcl-2-interacting / Atg6/Beclin / Atg6/Beclin C-terminal domain superfamily / Atg6, BARA domain / Atg6/beclin, coiled-coil domain / Apg6 BARA domain / Apg6 coiled-coil region / Apoptosis regulator, Bcl-2 / Apoptosis regulator, Bcl-2/ BclX ...Beclin-1, BH3 domain / Beclin-1 BH3 domain, Bcl-2-interacting / Atg6/Beclin / Atg6/Beclin C-terminal domain superfamily / Atg6, BARA domain / Atg6/beclin, coiled-coil domain / Apg6 BARA domain / Apg6 coiled-coil region / Apoptosis regulator, Bcl-2 / Apoptosis regulator, Bcl-2/ BclX / Apoptosis regulator, Bcl-2, BH4 motif, conserved site / Apoptosis regulator, Bcl-2 family BH4 motif signature. / Apoptosis regulator, Bcl-2 protein, BH4 / Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2 family BH4 motif profile. / BH4 Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily Similarity search - Domain/homology
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